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Ketamine's Impact on Opioid Use, Pain, and Mental Health in Polytraumatized Orthopedic Patients: A Randomized Controlled Trial (KOPM)
The goal of this clinical trial is to learn if ketamine, given during surgery, can help improve recovery for adults with serious orthopedic trauma. The study w…
Investigating the Effects of Social Stress on Brain Imaging
The purpose of this study is to examine whether experiencing a social stressor prior to the collection of neuroimaging measures is associated with differences …
Using Rural Community Paramedicine to Engage Lower-Motivated Smokers: Spreading an Effective mHealth-Assisted Intervention to Motivate Cessation
The study team proposes a multi-level trial to test 1) novel implementation programs in rural counties designed to increase access to 2) recent advances in tob…
Mechanisms Underlying Efficacy of Prolonged Exposure
The primary objective of this research is to collect pilot data that demonstrates that proposed neural, psychophysiological and subjective markers measured bef…
What Makes a Responder, a Responder? Biomarkers to Help Identify Responders and Resistors to High-intensity Interval Training for Lower Extremity Chronic Stroke
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some …
Intracranial Investigation of Neural Circuity Underlying Human Mood
Depression is one of the most common disorders of mental health, affecting 7-8% of the population and causing tremendous disability to afflicted individuals an…
INTEGRATED CHILDHOOD ACTIVITY AND NUTRITION (ICAN) STUDY
This study is a multi-functional integrated research and education project to prevent losses in academic achievement, cognitive function, and behavioral health…
Individually Targeted Neuromodulation for Contamination-based Obsessive-compulsive Disorder
Patients with obsessive-compulsive disorder (OCD) experience a wide array of different types of obsessions and compulsions. However, current treatments for OCD…
The PREGNANT (Pregnant Resident Empowerment, GuidaNce, and Advocacy iN Training) Coaching Project
This is a mixed-methods study designed to develop and evaluate an innovative coaching program for physician trainee mothers. Approximately 48 participants will…
Improving Care Transitions and Self-care Among Informal Caregivers of Hospitalized Older Adults Through Digital Tools
The goal of this randomized controlled trial is to examine the effect of a virtual face-to-face health coach intervention to improve self-care among caregivers…
Social Media Use Study
The investigators will be randomizing 300 college student participants with high levels of social media use into either a 1) control condition (no intervention…
Safety, Tolerability, and Efficacy of SRX246, a Vasopressin 1a Receptor Antagonist, in Aggressive Participants With Fragile X Syndrome
The goal of this clinical trial is to learn if drug SRX246 works to treat irritability, agitation, aggression and self-injury (IAAS) behaviors in adult males w…