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6 recruiting studies matching your filters

Phase I Clinical Trial of GPC2 Chimeric Antigen Receptor T (GPC2-CAR T) Cells for Relapsed or Refractory Medulloblastoma in Children and Young Adults

This is a single-site, open-label Phase I treatment study evaluating the manufacturing feasibility and safety of chimeric antigen receptor (CAR) T cells target…

MedulloblastomaCentral Nervous System Embryonal TumorRefractory Medulloblastoma+7 more

Estimated

~$10 – $6,250

Stanford UniversityNCT07087002

Phase 1

A Phase 1/1b Study of Autologous b7-h3 Chimeric Antigen Receptor t Cells (b7-h3.cd28z.Cart) in Children and Young Adults With Recurrent or Progressive Cns Neoplasms Expressing b7-h3 Target

The purpose of this research study is to test the safety and effectiveness of a cell therapy at different doses for children and young adults with recurrent or…

Central Nervous System NeoplasmsBrain TumorBrain Tumor, Recurrent+11 more

Estimated

~$10 – $7,500

Robbie MajznerNCT07390539

Phase 1

A Phase I/II Study Using Eflornithine (DFMO) and AMXT 1501 for Relapsed and Refractory Neuroblastoma, CNS Tumors, and Sarcomas

The purpose of this study is to evaluate the investigational oral drug AMXT 1501 in combination with oral eflornithine (DFMO). An investigational drug is one t…

Atypical Teratoid/Rhabdoid TumorEmbryonal Tumor With Multilayered RosettesEwing Sarcoma+4 more

Estimated

~$10 – $6,250

Milton S. Hershey Medical CenterNCT06465199

Phase 2

PNOC031: Protocol for Embryonal Tumor With Multilayered Rosettes (ETMR)

This is an open-label, comprehensive, iterative investigation of evaluating the use of induction chemotherapy, high-dose chemotherapy, and focal radiation ther…

Embryonal Tumor With Multilayered RosettesEmbryonal Tumor With Multilayered Rosettes, Nos

Estimated

~$10 – $5,625

University of California, San FranciscoNCT06861244

Phase 1

Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)

This is an open-label phase 1 safety and feasibility study that will employ multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against prote…

Medulloblastoma, ChildhoodAtypical Teratoid/Rhabdoid Tumor of CNSEmbryonal Tumor With Multilayered Rosettes+3 more

Estimated

~$10 – $5,625

Children's National Research InstituteNCT06193759

ETMR One: An International Registry and Research Platform for Children With Embryonal Tumor With Multilayer Rosettes

This research is being done to find out more information about a brain tumor called Embryonal Tumor with Multilayer Rosettes (ETMR) by collecting medical infor…

Embryonal Tumor With Multilayered Rosettes

Estimated

~$10 – $1,125

Hackensack Meridian HealthNCT04794686