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231 recruiting studies matching your filters

High Relaxivity Contrast Agent for Cardiac MR in the Myocardial Scar Assessment

Elucirem (Gadopiclenol) is a new macrocyclic gadolinium-based contrast agent (GBCA) with high relaxivity indicated for use in adults and children aged 2 years …

Myocardial Fibrosis

Estimated

~$10 – $6,250

Johns Hopkins UniversityNCT05954559

Phase 2

Investigator-Initiated, Open-Label, Phase II Trial of Selinexor in Combination With Pacritinib in Patients With Myelofibrosis Who Are JAK Inhibitor-Naïve and Have Cytopenias (ILLUMINATE)

This is a phase II, multicenter, open-label trial evaluating the safety and efficacy of pacritinib and selinexor in JAK inhibitor naïve patients with anemia an…

MyelofibrosisPost-polycythemia Vera MyelofibrosisPost-essential Thrombocythemia Myelofibrosis

Estimated

~$10 – $7,500

John MascarenhasNCT07447817

Observational

Exploring Caregiver Needs While Supporting People with CF Learning About Lung Transplant

Lung transplant is an option for treating end-stage lung disease in cystic fibrosis (CF). In the United States, more people with CF and low lung function die e…

Cystic Fibrosis

Estimated

~$10 – $6,250

University of WashingtonNCT06032273

Phase 1

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

AsthmaCOPDInterstitial Lung Disease+4 more

Estimated

~$10 – $7,500

Mario Castro, MD, MPHNCT04624490

Impact of Highly Effective Modulator Therapy on Sinonasal Microbial Communities, Host Mucosal Inflammatory Environment and Quality of Life in Adults With Cystic Fibrosis

The goal of this observational study is to learn about the effects of a specific cystic fibrosis therapy (Cystic Fibrosis Transmembrane Conductance Regulator M…

Cystic Fibrosis

Estimated

~$10 – $750

Dartmouth-Hitchcock Medical CenterNCT05982795

Observational

ACT With CF Self-Help Toolkit

Acceptance and Commitment Therapy (ACT) tailored to meet the needs of adults living with cystic fibrosis (ACT with CF) is a newer form of talk therapy that has…

Cystic Fibrosis (CF)Depressive and Anxiety DisordersPsychological Flexibility

Estimated

~$10 – $6,250

Thomas Jefferson UniversityNCT07436351

Phase 1

A Phase 1 Open Label Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PHIN-214 in Adults With Child Pugh A and B Cirrhosis

This 2-part study will evaluate PHIN-214 given as a single one-time dose (Part 1) and in multiple doses (given as daily doses for 28-days) (in Part 2). Specifi…

Cirrhosis, LiverLiver FibrosisAscites Hepatic

Estimated

~$10 – $8,750

PharmaINNCT05490888

A Single-Site Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical resear…

Estimated

~$10 – $1,050

Sanguine BiosciencesNCT05635266

Phase 1

Phase Ib, Open-label Study of Add on Therapy With CK0804 in Participants With Myelofibrosis, With Suboptimal Response to Ruxolitinib

To assess the safety and tolerability of CK0804 as add-on therapy in participants with myelofibrosis, with suboptimal response to ruxolitinib

Myelofibrosis

Estimated

~$10 – $8,750

Cellenkos, Inc.NCT05423691

Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies

The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misal…

Congenital Fibrosis of Extraocular MusclesDuane Retraction SyndromeDuane Radial Ray Syndrome+23 more

Estimated

~$10 – $750

Boston Children's HospitalNCT03059420

Phase 2

A Phase 2 Open-label Study to Evaluate Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Primary or Secondary Myelofibrosis

The purpose of this Phase 2 study is to evaluate the efficacy and safety of momelotinib (MMB) in combination with luspatercept (LUSPA) in participants with tra…

Primary MyelofibrosisMyelofibrosis; Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis

Estimated

~$10 – $7,500

GlaxoSmithKlineNCT06517875

Idiopathic Pulmonary Fibrosis, a Disease Initiated by Mucociliary Dysfunction

This study seeks to screen first degree family members of people with Idiopathic Pulmonary Fibrosis (IPF) for the earliest signs of lung fibrosis.

Idiopathic Pulmonary Fibrosis (IPF)

Estimated

~$10 – $750

University of Colorado, DenverNCT03478553