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Phase 1
IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease
This is a single center, open-label, prospective, investigation to quantify the effects liver congestion and fibrosis has on hepatic drug metabolism and transp…
Fontan Circulation
Children's Mercy Hospital Kansas CityNCT06324396
Phase 2
Cardiac and Metabolic Effects of Dapagliflozin in the Failing Fontan Circulation: A Phase II, Prospective, Double-Blind Study
The purpose of this research is to determine whether treatment with the study drug dapagliflozin for 3 months affects peripheral venous pressure at rest and du…
Fontan CirculationSingle Ventricle Heart DiseaseHFpEF - Heart Failure With Preserved Ejection Fraction
Mayo ClinicNCT06762964