The aim of this study is to investigate whether venous compression garments increase exercise stroke volume in patients with Fontan circulation. To address thi…

Single-ventricleFontan Circulation

~Estimated

~$10 – $6,250

University of Texas Southwestern Medical CenterNCT07220226

Phase 1

IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease

This is a single center, open-label, prospective, investigation to quantify the effects liver congestion and fibrosis has on hepatic drug metabolism and transp…

Fontan Circulation

~Estimated

~$10 – $6,250

Children's Mercy Hospital Kansas CityNCT06324396

Phase 2

Cardiac and Metabolic Effects of Dapagliflozin in the Failing Fontan Circulation: A Phase II, Prospective, Double-Blind Study

The purpose of this research is to determine whether treatment with the study drug dapagliflozin for 3 months affects peripheral venous pressure at rest and du…

Fontan CirculationSingle Ventricle Heart DiseaseHFpEF - Heart Failure With Preserved Ejection Fraction

~Estimated

~$10 – $6,250

Mayo ClinicNCT06762964