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67 recruiting studies matching your filters

A Pilot Study of FES Imaging to Optimize Tamoxifen Dose for Metastatic Breast Cancer Patients With ESR1 Mutations

Despite broad advancements in endocrine therapy for ERα+ breast cancer, resistance ultimately develops. A common driver of resistance are known ESR1 mutations …

ERα+ Breast CancerESR1 Gene Mutation

Estimated

~$10 – $6,250

University of Wisconsin, MadisonNCT04174352

Observational

EQUAL: EGFR ctDNA QUantative Assessment for Lung Cancer Screening in Asian and Latinx Populations

This research study is studying a new blood test to screen for Epidermal Growth Factor Receptor (EGFR) positive lung cancer in healthy individuals at risk for …

Lung CancerEGFR Gene Mutation

Estimated

~$10 – $7,500

Dana-Farber Cancer InstituteNCT06716580

Phase 1

Combination Therapy of Niraparib and Irinotecan in Cancers With Mutations in DNA Repair Genes

The purpose of this phase 1 clinical trials is to determine whether niraparib (a Poly (ADP-ribose) polymerase inhibitor (PARPi)) can be safely combined with ir…

Metastatic Solid TumorBRCA1 MutationBRCA2 Mutation+2 more

Estimated

~$10 – $5,625

University of California, San FranciscoNCT05694715

Phase 2

PEMIGIST: Phase 2 Study of Pemigatinib (INCB054828) in the Treatment of Patients With Advanced SDH-deficient Gastrointestinal Stromal Tumor (GIST)

The purpose of this study is to determine how effective the drug pemigatinib is as a treatment option for advanced succinate dehydrogenase (SDH)-deficient gast…

SDH Gene MutationGastrointestinal Stromal Tumor

Estimated

~$10 – $7,500

Dana-Farber Cancer InstituteNCT07434843

Iodine-124 Evuzamitide PET/CT Imaging in Carriers of TTR Mutations

The purpose of this study is to determine if TTR gene carriers have early signs of a type of heart disease called amyloidosis using a new radiotracer dye (iodi…

ATTRATTR Gene MutationCardiomyopathy+1 more

Estimated

~$10 – $750

University of Texas Southwestern Medical CenterNCT07591038

Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

Primary objective: To identify older adults with transthyretin cardiac amyloidosis (ATTR-CA) early in the course of the illness, at a time when disease modify…

Lumbar Spinal StenosisCardiac AmyloidosisATTR Amyloidosis Wild Type+3 more

Estimated

~$10 – $750

Columbia UniversityNCT06034405

Phase 1

A Phase 1, Open-label, Dose Escalation and Dose Expansion, Multicenter Clinical Trial to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of ZE46-0134 in Adults With FLT3 Mutated or Spliceosome Mutated Relapsed or Refractory Acute Myeloid Leukemia (AML)

This is a clinical study aiming to assess pharmacokinetics, pharmacodynamics and preliminary efficacy of ZE46-0134 in patients with FLT3 and spliceosome mutate…

AML With Gene Mutations

Estimated

~$10 – $8,750

Lomond Therapeutics Holdings, Inc.NCT06366789

The Natural History of TRPV4 Neuropathy

The goal of this research is to document the natural history of neuropathy in patients with a confirmed genetic mutation in the TRPV4 gene. The investigators a…

TRPV4 Gene Mutation

Estimated

~$10 – $750

Johns Hopkins UniversityNCT05600764

Phase 2

Phase 1 / 2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects With Non-Small Cell Lung Cancer With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

To assess: * efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification, solid …

Solid TumorsAdvanced CancerRenal Cancer+15 more

Estimated

~$10 – $8,750

Apollomics Inc.NCT03175224

Phase 1

A Phase 1/2, Dose Escalation and Expansion Trial to Evaluate the Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma

This trial will evaluate the safety, tolerability, and preliminary efficacy of tegavivint as monotherapy (single) and in combination with standard therapies in…

Metastatic Colorectal Carcinoma (mCRC)Colorectal Cancer (CRC)Adenomatous Polyposis Coli (APC) Gene Mutation+1 more

Estimated

~$10 – $7,500

HonorHealth Research InstituteNCT07463599

Li-Fraumeni & TP53: Understanding and Progress (LiFT UP)

The purpose of this research study is to learn more about variants in the TP53 gene both associated with Li-Fraumeni Syndrome (LFS), a hereditary cancer risk c…

Li-Fraumeni SyndromeTP53 Gene MutationHereditary Cancer Syndrome+2 more

Estimated

~$10 – $1,125

Dana-Farber Cancer InstituteNCT04541654

Phase 1

Phase 1 Study of Venetoclax/Azacitidine or Venetoclax in Combination With Ziftomenib or Standard Induction Cytarabine/Daunorubicin (7+3) Chemotherapy in Combination With Ziftomenib for the Treatment of Patients With Acute Myeloid Leukemia

Ziftomenib is an investigational drug in development for the treatment of patients with acute myeloid leukemia (AML) with certain genetic alterations. This pr…

Acute Myeloid LeukemiaMixed Lineage Leukemia Gene MutationRefractory AML+7 more

Estimated

~$10 – $8,750

Kura Oncology, Inc.NCT05735184