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185 recruiting studies matching your filters

Prognostic Factors, Surgical Management and Survival of Glioblastoma Patients: a Multicenter Prospective Study

Glioblastoma (GBM) is the most common and aggressive primary tumor of the adult central nervous system (CNS), with a poor prognosis and median overall survival…

Glioblastoma

Estimated

~$10 – $750

Larissa University HospitalNCT07162324

Phase 1

Biologic Association Between Metabolic MR-PET and Tissue Measures of Glycolysis in Brain Tumors Visualization, Quantitation, and Targeting of Infiltrating Glioblastoma Cells With pH Sensitive Amine Chemical Exchange Saturation Transfer Magnetic Resonance Imaging-KL2TR001882

The purpose of this project is to validate a new combined MRI and PET imaging technique as a biomarker or measure of glycolysis in brain tumors. To accomplish …

Glioblastoma MultiformeGlycolytic IndexEpidermal Growth Factor Receptor

Estimated

~$10 – $6,250

Jonsson Comprehensive Cancer CenterNCT06059690

Phase 1

Targeting Infiltrating Glioblastoma Via pH Sensitive Visualization of Tumor and pH Modulation Through Bicarbonate Transporter SLC4A4

Glioblastoma is an infiltrating tumor that is difficult to visualize in surgery and on standard images. A special pH (acid-base) related magnetic resonance ima…

Glioblastoma

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT07218367

Phase 1

Phase I Clinical Trial of Anti-CD3 × Anti-EGFR Bispecific-armed T Cells (EGFR BATs) and Low-Intensity Focused Ultrasound (LIFU) Blood-brain Barrier Opening in Patients With MGMT Unmethylated Glioblastoma (GBM)

This is a phase 1 study for patients with newly diagnosed MGMT unmethylated IDH wild-type glioblastoma utilizing autologous activated T-cells armed with bispec…

Glioblastoma (GBM)

Estimated

~$10 – $6,250

University of VirginiaNCT07343986

Key Longitudinal Associations With Risk and Glioblastoma Outcomes

The goal of this observational study is to find out what factors affect the health and risks in adults with glioblastoma (GBM), a grade 4 brain cancer. The ma…

Glioblastoma

Estimated

~$10 – $750

Duke UniversityNCT06625684

Phase 1

A Phase 1 / 2 Study of Visudyne (Liposomal Verteporfin) in Persons with Recurrent High Grade EGFR-Mutated Glioblastoma

This phase I/II trial studies the side effects and best dose of Visudyne (liposomal verteporfin) and to see how well it works in treating patients with high gr…

GlioblastomaRecurrent Glioblastoma

Estimated

~$10 – $6,250

Emory UniversityNCT04590664

Phase 2

Cancer CARE Beyond Walls - A Pilot of a Randomized, Pragmatic Trial of Cancer Directed Therapy Administration in the Patients' Homes Versus in Clinic

This clinical trial studies the effect of cancer directed therapy given at-home versus in the clinic for patients with cancer that may have spread from where i…

Advanced Anal CarcinomaAdvanced Biliary Tract CarcinomaAdvanced Bladder Carcinoma+41 more

Phase 2

A Phase II Open Label, Randomized Study Testing the Efficacy of Retifanlimab in Combination with Bevacizumab and Hypofractionated Radiotherapy in Patients with Recurrent GBM

This phase II trial tests how well retifanlimab with bevacizumab and hypofractionated radiotherapy, compared to bevacizumab and hypofractionated radiotherapy a…

Recurrent GlioblastomaRecurrent WHO Grade 4 Glioma

Estimated

~$10 – $7,500

Academic and Community Cancer Research UnitedNCT06160206

The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)

There are no guidelines or prospective studies defining the optimal surgical treatment for gliomas of older patients (≥70 years) or those with limited function…

GlioblastomaGlioblastoma, IDH-wildtypeGlioblastoma Multiforme+2 more

Estimated

~$10 – $1,125

Jasper GerritsenNCT06146725

Phase 3

Advanced MRI for Visualization and Quantification of the Tumor Immune Microenvironment (TIME) in Glioblastoma

This phase III trial is evaluating whether a combination of three advanced magnetic resonance imaging (MRI) techniques, including chemical exchange saturation …

Glioblastoma

Estimated

~$10 – $6,250

Jonsson Comprehensive Cancer CenterNCT07461948

Phase 1

Pilot Study of Sonodynamic Therapy With 5-ALA for the Treatment of Recurrent Glioblastoma Using Neuronavigation-Guided Low-Intensity Focused Ultrasound

Patients diagnosed with glioblastoma (GBM) are faced with limited treatment options. This pilot study will evaluate the safety and feasibility of combining an …

Recurrent GlioblastomaGlioblastoma MultiformeGBM

Estimated

~$10 – $7,500

Shayan Moosa, MDNCT06039709

Phase 1

Phase I Study of Intraventricular Infusion of T Cells Expressing B7-H3 Specific Chimeric Antigen Receptors (CAR) in Subjects With Recurrent or Refractory Glioblastoma

The purpose of this study is to test the safety of using T lymphocyte chimeric antigen receptor cells against the B7-H3 antigen (CAR.B7-H3T cells) in patients …

Glioblastoma Multiforme

Estimated

~$10 – $6,250

UNC Lineberger Comprehensive Cancer CenterNCT05366179