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8 recruiting studies matching your filters

Clinical Trial to Evaluate Short-term Safety of Subconjunctival Adalimumab in Combination With Type 1 Boston Keratoprosthesis Implantation

This trial is studying the safety and tolerability of receiving an injection of adalimumab (Humira) during the Boston Keratoprosthesis (KPro) surgery.

Penetrating KeratoplastyMultiple Graft FailureOcular Cicatricial Pemphigoid+1 more

Estimated

~$10 – $7,500

Massachusetts Eye and Ear InfirmaryNCT06926478

Integration of Donor-derived Cell-free DNA With HLA-DR+TNFR2+ Regulatory T Cell in the Prediction of Acute Rejection and Graft Function After Kidney Transplantation

Acute rejection after kidney transplantation should ideally be diagnosed prior to immunologic injury in a non-invasive fashion in order to improve long-term gr…

Acute Rejection of Renal TransplantGraft Failure

Estimated

~$10 – $750

Loma Linda UniversityNCT05084768

Phase 1

Multi-institutional Prospective Pilot Research of Imaging and Blood Biomarker EValuation of Engraftment After ALlogeneic Hematopoietic Stem Cell Transplantation

The purpose of this study is to find new tests that could help determine if the newly infused bone marrow cells are growing well after bone marrow transplantat…

Primary Graft Failure

Estimated

~$10 – $6,250

University of OklahomaNCT03541889

Observational

CD34+ Selected Donor Cell Boost for Management of Poor Graft Function or Primary or Secondary Graft Failure Following Allogeneic Hematopoietic Stem Cell Transplantation

The proposed trial is a single arm, non-randomized, single center pilot study utilizing CliniMACS CD34 Reagent System for patients following allogeneic hematop…

Graft FailurePoor Graft Function

Estimated

~$10 – $7,500

NYU Langone HealthNCT06569082

Phase 1

Ruxolitinib-Enhanced Conditioning for Pediatric and Young Adult Patients With Symptomatic Sickle Cell Disease Undergoing Haploidentical Hematopoietic Cell Transplantation

This trial will determine whether adding ruxolitinib to a reduced intensity conditioning (RIC) regimen reduces the rate of graft failure following haploidentic…

Sickle Cell DiseaseHematopoetic Stem Cell TransplantHaploidentical Hematopoietic Stem Cell Transplant+2 more

Estimated

~$10 – $6,250

Arkansas Children's Hospital Research InstituteNCT07252050

Phase 2

Allogeneic Hematopoietic Stem Cell Transplant for Patients With High Risk Hemoglobinopathies and Other Red Cell Transfusion Dependent Disorders

A single center, open label, interventional, phase II trial for donor transplant for high risk hemoglobinopathies and other red cell transfusion dependent diso…

Graft FailureSickle Cell DiseaseHemoglobinopathies

Estimated

~$10 – $6,250

Masonic Cancer Center, University of MinnesotaNCT06872333

Phase 1

Emapalumab for the Prevention of Graft Rejection in Hematopoietic Stem Cell Transplant (HSCT) Recipients

The investigators hypothesize that graft rejection after hematopoietic stem cell transplant (HSCT) is primarily driven by interferon gamma, and prophylactic in…

Hematopoietic Stem Cell TransplantationGraft Failure

Estimated

~$10 – $5,625

Children's Hospital Medical Center, CincinnatiNCT07244419

Treatment of Graft Failure After Hematopoietic Stem Cell Transplantation

This is a guideline for the treatment of graft failure after hematopoietic stem cell transplant (HSCT). This regimen, consisting of cyclophosphamide and fludar…

Primary Graft FailureSecondary Graft Failure

Estimated

~$10 – $6,250

Masonic Cancer Center, University of MinnesotaNCT02161783