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7 recruiting studies matching your filters

A Phase II Prospective Study Evaluating Selective Depletion of CD45RA+ (Naïve) T Cells (TND) From Peripheral Blood Stem Cell (PBSC) Grafts for Prevention of Graft Versus Host Disease (GVHD) in Non-Malignant Diseases (NMDs)

This phase II trial investigates how well a naive T cell depleted graft work for the reduction of graft versus host disease in patients with non-malignant dise…

Bone Marrow FailureHemoglobinopathiesPrimary Immune Deficiency (PID)+4 more

Estimated

~$10 – $6,250

Fred Hutchinson Cancer CenterNCT07660783

Phase 2

A Multipart, Open-label, Single-arm, Multicenter Study to Evaluate the Safety, Efficacy and Pharmacokinetics of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH)

Hemophagocytic lymphohistiocytosis is a rare, aggressive and life-threatening syndrome of excessive immune activation. Secondary hemophagocytic lymphohistiocyt…

Secondary Hemophagocytic Lymphohistiocytosis (sHLH)

Estimated

~$10 – $8,750

Electra Therapeutics Inc.NCT05416307

National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) - A Collaborative Initiative to Improve Care of Children With Complex Congenital Heart Disease

The purpose of this initiative is to improve care and outcomes for infants with HLHS by expanding the NPC-QIC national registry to gather clinical care process…

Hypoplastic Left Heart Syndrome (HLHS)

Estimated

~$10 – $675

Children's Hospital Medical Center, CincinnatiNCT02852031

Phase 2

Cord Blood Transplantation in Children and Young Adults With Hematologic Malignancies and Non-malignant Disorders

This is a single-arm study to investigate 1-year treatment related mortality (TRM) in patients with life threatening non-malignant and malignant hematologic di…

AMLALLMDS+6 more

Estimated

~$10 – $6,250

Memorial Sloan Kettering Cancer CenterNCT04644016

Phase 1

Pilot, Open-Label Study Evaluating the Safety and Feasibility of Using Rescue Therapies for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome

This is a pilot, open-label study to assess the safety and feasibility of using investigational drug(s) as rescue therapies for CAR T cell related CRS and HLH-…

CRS - Cytokine Release SyndromeHLH

Estimated

~$10 – $6,250

University of PennsylvaniaNCT05306080

Phase 1

Phase 1/2 Study: CD45RA Depleted Peripheral Stem Cell Addback to Prevent Viral and Fungal Infections Following Alternative Donor TCRab/CD19 Depleted Hematopoietic Stem Cell Transplant

The major morbidities of allogeneic hematopoietic stem cell transplant (HSCT) using donors that are not human leukocyte antigen (HLA) matched siblings are graf…

LeukemiaHigh Risk Acute Lymphoblastic LeukemiaHigh Risk Acute Myeloid Leukemia+11 more

Estimated

~$10 – $6,250

Children's Hospital of PhiladelphiaNCT06839456

Phase 2

Prospective, Open-labeled, Single-arm Clinical Trial to Evaluate the Safety and Efficacy of the Second-generation Tissue Engineered Vascular Graft as Vascular Conduits for Extracardiac Total Cavopulmonary Connection.

A single arm clinical trial evaluating the safety and efficacy of the second generation TEVG as vascular conduits for extracardiac total cavopulmonary connecti…

HLH - Hypoplastic Left Heart SyndromeDORVDILV - Double Inlet Left Ventricle+8 more

Estimated

~$10 – $6,250

Nationwide Children's HospitalNCT04467671