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Phase 2
Phase II Study of First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients
The purpose of this research is to see what effects the treatment regimen chemotherapy (carboplatin and paclitaxel) plus immunotherapy (pembrolizumab), has on …
Head Neck CancerMetastatic Squamous Cell CarcinomaOral Cavity Squamous Cell Carcinoma+3 more
Wake Forest University Health SciencesNCT04858269
Phase 1
Study of Intratumoral Injections of VLPONC-01 in Head and Neck Cancer
The goal of this clinical trial is to assess the safety and tolerability of a virus replicon particle (VRP) encapsulated saRNA encoding IL-12 when injected int…
Head and Neck Cancers- Squamous CellHead and Neck CancerSolid Tumors+10 more
VLP TherapeuticsNCT06736379
Phase 1
Phase 1b/2a Study of RiMO-301 and Hypofractionated Radiotherapy With A PD-1 Inhibitor for the Treatment of Unresectable, Recurrent or Metastatic Head-Neck Cancer
This is a prospective, open-label, single arm, non-randomized study of RiMO-301 with hypofractionated radiation and a PD-1 Inhibitor in patients with unresecta…
Head Neck CancerIntratumoral Injection
Coordination Pharmaceuticals, Inc.NCT05838729
Observational
Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy for Pain Palliation in Head, Neck, & Brachial Cancer
This phase 1 multi-site study investigates the safety and initial effectiveness of focused ultrasound lesioning of the contralateral mesencephalon for severe, …
Head Neck CancerSquamous Cell Cancer of Head and Neck (SCCHN)Cancer Pain
University of VirginiaNCT07405645