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Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET …
A Two-Part Clinical Study to Evaluate the Effects of Multiple Doses of Itraconazole on the Single-Dose Pharmacokinetics of MK-2828 (Part 1) and Multiple Doses of MK-2828 on the Single-Dose PK of Midazolam (Part 2) in Healthy Participants
The main goals of this study are: * To learn what happens to one dose of MK-2828 in a healthy person's body over time when it is taken with itraconzole * To l…
The SolanoConnex Trial: A Single-blind Randomized Controlled Trial of a Digital and Community-based Mental Health Access Project
The goal of this study is to evaluate the effectiveness of the SolanoConnex.org program on help-seeking attitudes and help-seeking behaviors among users compar…
Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to gro…
TransHealthGUIDE: Transforming Health for Gender-Diverse Young Adults Using Interventions to Drive Equity
This is a randomized controlled trial to test the effectiveness of an interactive educational app-based digital intervention that provides knowledge and suppor…
Pilot Testing an Intervention to Enhance Coping and Increase Mental Health Help-seeking Among Transition-age Youth in Foster Care
This study will deploy a scalable secondary prevention program that leverages existing foster youth transition services to improve mental health functioning an…
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Dose Study to Characterize the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY4088044 in Healthy Participants.
The purpose of this study is to evaluate how well LY4088044 is tolerated and what side effects may occur in healthy participants. The study drug will be admini…
Evaluation of Telehealth Services on Mental Health Outcomes for People With Intellectual and Developmental Disabilities
Roughly 40% of those with intellectual and developmental disabilities (IDD) have mental health needs, which is twice the national average. Nevertheless, there …
Optimizing Ultrasound-induced Anti-inflammation in Human Subjects
This is a feasibility study to determine whether pulsed ultrasound stimulation targeting the splenic nerve or the cervical vagus nerve can elicit an anti-infla…
Veteran Social Support Intervention for Enhancing Smoking Treatment Utilization and Cessation
This study is recruiting Veterans who currently smoke cigarettes and support persons who are nominated by the Veterans. The purpose of this study is to assist …
Evaluating an Interactive Digital Toolkit for Women's PrEP Implementation
The goal of this study is to test if a Digital PrEP Toolkit helps cisgender women learn about and access PrEP in Alabama and Mississippi. PrEP is a medication …
Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder
The goal of this research study is to examine the endocannabinoid (eCB) function in vivo in individuals with opioid use disorder (OUD) by measuring cannabinoid…