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185 recruiting studies matching your filters

A Phase 1 Open-label, Multiple Dose Study of Upadacitinib, Tofacitinib, and Baricitinib in Healthy Subjects to Evaluate Pharmacodynamic Biomarkers

This is a Phase 1, open label, five arm study to evaluate the pharmacodynamic effects of multiple doses of upadacitinib, tofacitinib, and baricitinib in health…

Role of Metal Ion Transporter ZIP8 in Alcohol Related Behaviors

Background: Alcohol use disorder (AUD) can damage people s health, work, and family. Researchers want to know more about why some people are more vulnerable t…

Healthy Volunteer

Estimated

~$10 – $5,625

National Institute on Alcohol Abuse and Alcoholism (NIAAA)NCT06819189

Phase 1

A Two-Part Phase 1, Randomized, Double-Blind, Placebo-Controlled First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of REGN20423 in Adult Healthy Participants and Adult Participants With Atopic Dermatitis

This study will test a study medicine called REGN20423 to see how effective it is in healthy participants (in Part A) and participants with atopic dermatitis (…

Healthy VolunteerAtopic Dermatitis

Estimated

~$10 – $8,750

Regeneron PharmaceuticalsNCT07527923

Phase 1

A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Ascending Oral Doses of IBI3042 in Healthy Adult Participants

This is a randomized, investigator- and participant-blinded, placebo-controlled, parallel-group, dose-escalation Phase 1 study to evaluate the safety, tolerabi…

Healthy Volunteers (HV)

Estimated

~$10 – $8,750

Fortvita Biologics (USA)Inc.NCT07842393

Phase 1

A Phase 1, Randomized, Double-blind, Placebo-controlled, 2-Part Study to Assess Safety, Tolerability and Pharmacokinetics of Single and Multiple Oral Doses of INS1033 in Healthy Participants

The primary objective of this study is to assess the safety and tolerability of single and multiple ascending doses of INS1033 in healthy participants.

Healthy Volunteers

Estimated

~$10 – $8,750

Insmed IncorporatedNCT07765706

Phase 1

Phase 1 Challenge Study Using rDEN2delta30-7169 to Evaluate Host-Pathogen Interactions in Primary, Homotypic, and Heterotypic Dengue Virus Infection

Background: Dengue is a viral disease spread by mosquitoes. Most people bitten by mosquitoes carrying dengue viruses do not get sick, but severe cases can cau…

Healthy VolunteersDengueHuman Challenge Trial

Estimated

~$10 – $5,625

National Institute of Allergy and Infectious Diseases (NIAID)NCT07706686

Phase 1

A Phase 1/2, Randomized, Controlled, Observer-Blind Study in Adults 60 Years of Age and Older to Evaluate the Immunogenicity and Safety of Different Dose Levels of a Bivalent Vaccine Candidate Against Respiratory Syncytial Virus (RSV) and Human Metapneumovirus (HMPV)

This study is a Phase 1/2, randomized, observer-blind, active and placebo-controlled, multi-center study to be conducted in approximately 2400 adults 60 years …

Respiratory Syncytial Virus ImmunizationHuman Metapneumovirus ImmunizationHealthy Volunteers

Measurement of Pulmonary Inflammation Using 18F-NOS Positron Emission Tomography (PET/CT) in E-cigarette Users

The purpose of this research is to measure the extent of lung inflammation between different groups of participants using a radioactive tracer called \[18F\]NO…

Smoking, CigaretteSmoking E-cigaretteHealthy Volunteer

Estimated

~$10 – $6,250

University of PennsylvaniaNCT03721822

Phase 1

A Phase 1, Open-label, Randomized, Single-dose Study to Assess the Relative Bioavailability of Irafamdastat (BMS-986368) Oral Disintegrating Tablet, Oral Disintegrating Tablet Suspension, and Capsule Sprinkles to the Reference Capsule and to Assess the Food Effect on the Pharmacokinetics of Irafamdastat Administered as Oral Disintegrating Tablet in Healthy Adult Participants

The purpose of this study is to evaluate the relative bioavailability of irafamdastat and to assess food-effect on the pharmacokinetics (PK) of irafamdastat OD…

Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations

The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenz…

No Disease or Condition is Being Directly StudiedThe Focus of the Study in Healthy Volunteers

Estimated

~$10 – $6,250

Lake Erie College of Osteopathic MedicineNCT07786467

Imaging Techniques in MRI

Background: \- Magnetic resonance imaging (MRI) scans must be performed according to specified sets of parameters that provide optimal images of each organ an…

Cardiac Risk FactorsHealthyHealthy Volunteers

Estimated

~$10 – $675

National Institutes of Health Clinical Center (CC)NCT01130545

Observational

A Placebo-controlled, Double-blind, Safety and Experience Evaluation of IgG Binding Protein LT (BP-LT).

This study evaluates the safety and tolerability of the food ingredient IgG Binding Protein LT (BP-LT) when added to a daily diet. BP-LT is a stable protein in…

Safety and Tolerability in Healthy Volunteers

Estimated

~$10 – $7,500

Bactolife A/SNCT07824011