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Phase 1
Multi-institutional Prospective Phase I Research of Expanded Multi-antigen Specifically Oriented Lymphocytes for the Treatment of VEry High Risk Hematopoietic Malignancies
This Phase I dose-escalation trial is designed to evaluate the safety of administering rapidly -generated tumor multi-antigen associated -specific cytotoxic T …
Relapsed/Refractory Hematopoietic Malignancies, Acute Myeloid Leukemia and MDS
Catherine BollardNCT02203903
Phase 1
A Phase I Study of Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Other Hematologic Malignancies
Background: Blood cancers (such as leukemias) can be hard to treat, especially if they have mutations in the TP53 or RAS genes. These mutations can cause the …
Malignancy, HematologicNeoplasms, HematologicNeoplasms, Hematopoietic+8 more
National Cancer Institute (NCI)NCT06904066