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3 recruiting studies matching your filters
Phase 1
JACOB: Joint Administration of cDNA for TP53, checkpOint Inhibition and Boost/Hypofractionated Radiation. A Phase 0/1 Study in Children With Recurrent, Progressive or Refractory CNS Malignancies.
This clinical trial is studying a drug called SGT-53 along with radiation and another drug called Nivolumab. It's for children with brain tumors that have come…
CNS MalignanciesMedulloblastoma RecurrentATRT Recurrent+4 more
Children's National Research InstituteNCT07017816
Phase 1
A Phase I/II Study of an AAV-1 Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma
The goal of this clinical trial is to first define the Safety and Optimal Biological Dose (OBD) of study drug TGX-007 and to then further investigate the safet…
Glioblastoma (GBM)High Grade GliomasRecurrent Glioblastoma+1 more
Trogenix ltdNCT07346144
Phase 1
Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)
High-grade gliomas (HGGs) are among the most aggressive and treatment-resistant brain tumors. Immunotherapy with checkpoint inhibitors like nivolumab has shown…
Brain CancerHGGGlioma+4 more
Eben RosenthalNCT07210632