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15 recruiting studies matching your filters
International Rare Histiocytic Disorders Registry (IRHDR)
The rare histiocytic disorders (RHDs) are characterized by the infiltration of one or more organs by non-LCH histiocytes. They can range from localized disease…
Rare Histiocytic Disorders (RHDs)Erdheim-Chester Disease (ECD)Rosai-Dorfman Disease (RDD)+7 more
Estimated
~$10 – $750
The Hospital for Sick ChildrenNCT02285582
Phase 2
Targeted Approach to Langerhans Cell Histiocytosis (LCH) Using MEK Inhibitor, Trametinib
The purpose of this Phase II clinical trial is to establish the safety and effectiveness of trametinib, a targeted therapy, for the treatment of newly or recen…
Langerhans Cell Histiocytosis
Estimated
~$10 – $7,500
Cook Children's Health Care SystemNCT06582745
Phase 2
A Phase 2 Study to Assess the Safety and Efficacy of Cobimetinib in Refractory Langerhans Cell Histiocytosis, LCH-Associated Neurodegenerative Disease, and Other Histiocytic Disorders.
This is a research study of a drug called cobimetinib in children and adults diagnosed with Langerhans cell histiocytosis (LCH), and other histiocytic disorder…
Langerhan's Cell HistiocytosisJuvenile XanthogranulomaErdheim-Chester Disease+4 more
Estimated
~$10 – $7,500
Carl AllenNCT04079179