The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ab…

HyperandrogenismPolycystic Ovary SyndromePuberty

~Estimated

~$10 – $6,250

University of VirginiaNCT03068910

Phase 1

Does Spironolactone Normalize Sleep-wake Luteinizing Hormone (LH) Pulse Frequency in Pubertal Girls With Hyperandrogenism? (CBS010)

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone norm…

HyperandrogenismPolycystic Ovary SyndromePuberty

~Estimated

~$10 – $6,250

University of VirginiaNCT04723862

Phase 1

Study to Assess Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism

The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces…

PubertyHyperandrogenism

~Estimated

~$10 – $6,250

University of VirginiaNCT00929006