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7 recruiting studies matching your filters

A Phase 3, Single-Arm, Open-label, Pivotal Study to Evaluate the Efficacy and Safety of Ersodetug Compared to Baseline in Patients With Inadequately Controlled Hypoglycemia Due to Tumor Hyperinsulinism (Tumor HI)

The objectives of this study are to evaluate the glycemic efficacy, safety, and tolerability of ersodetug as add-on to standard of care (SOC) therapy for treat…

Tumor Hyperinsulinism (Tumor HI)

A Pilot Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy for Patient With HER2-negative Early-stage Breast Cancer and Hyperinsulinemia

The primary objective of the study is to assess metabolic plasma markers of insulin resistance in patients with early-stage HER2-negative breast cancers receiv…

Breast CancerHyperinsulinismHER2-negative Breast Cancer

Estimated

~$10 – $6,250

Yale UniversityNCT05989347

Observational

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking …

Insulin ResistanceDepressionDepressive Disorder+5 more

Estimated

~$10 – $6,250

Colorado State UniversityNCT05543083

Measuring Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

The study aims to investigate the relationship between fasting insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across various demograp…

Insulin ResistancePolycystic Ovary SyndromeHyperinsulinism+2 more

Estimated

~$10 – $1,125

Ali ChappellNCT05950282

Phase 2

Use of18F-DOPA PET/MRI for the Detection and Localization of Focal Forms of Hyperinsulinism

The purpose of the study is to provide access to 18F-DOPA PET to patients at Washington University and assess the utility of 18F-DOPA PET/MRI as a preoperative…

Hyperinsulinism

Estimated

~$10 – $6,250

Washington University School of MedicineNCT05088798

Phase 1

The Use of Fluorodopa F 18 Positron Emission Tomography Combined With Computed Tomography in Congenital Hyperinsulinism and Insulinoma

Low blood sugars are known to cause brain damage in newborn babies. One of the most common causes of low blood sugars persisting beyond the new born period is …

Congenital HyperinsulinismInsulinoma

Estimated

~$10 – $7,500

Cook Children's Health Care SystemNCT02021604

Phase 2

18F-Fluoro-L- DOPA PET Imaging for the Detection and Localization of Focal Congenital Hyperinsulinism

The goal of this project is to determine the role of FDOPA/PET as a pre-operative diagnostic imaging procedure for differentiating focal and diffuse forms of c…

Congenital Hyperinsulinism

Estimated

~$10 – $7,500

Miguel PampaloniNCT04205604