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4 recruiting studies matching your filters
Phase 2
A Phase 2b, Double-Blind, Three Arm, Randomized, Placebo Controlled Trial With Restricted Response Adaptive Randomization Testing the Efficacy and Safety of High Dose Methylprednisolone or Equine Anti-Thymocyte Globulin as Treatment for Acute Liver Failure in Pediatric Patients
TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) is a multi-center, three arm, randomized, controlled trial of immunosuppressive therapy for children wi…
Acute Liver FailureFulminant Hepatic FailureHepatic Encephalopathy+2 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT04862221
Phase 2
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradia…
Common Variable Immunodeficiency (CVID)Primary Immune Regulatory DisorderImmune Dysregulation+12 more
Paul SzabolcsNCT07284641
Natural History Study for Genetic Diseases of Allergic Inflammation and Immune Dysregulation
This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic infl…
Immune DeficiencyImmune Dysregulation DisorderAllergic Inflammation
Columbia UniversityNCT05584488
Phase 4
Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use (MET-IH)
This randomized clinical trial (RCT) evaluates whether metformin can reduce systemic inflammation and improve immune function in individuals with a history of …
Systemic InflammationImmune DysregulationInjection Drug Use+1 more
University of Alabama at BirminghamNCT06829238