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6 recruiting studies matching your filters

Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma Across the Military Healthcare System

The goal of this observational cohort study is to learn how toxin and occupational exposures, germline genetic variation, and immune dysregulation relate to B-…

Non-Hodgkin LymphomaLymphoma Non-HodgkinB-cell Lymphoma+1 more

Estimated

~$10 – $750

Henry M. Jackson Foundation for the Advancement of Military MedicineNCT07652580

Immune Dysregulation During Sepsis: A Natural History Cohort

Background: Sepsis is an illness that occurs when the body s immune system runs out of control. This can damage organs. Sepsis causes an estimated 1 in 5 deat…

SepsisSeptic ShockSepsis-Associated Immune Dysregulation

Estimated

~$10 – $675

National Heart, Lung, and Blood Institute (NHLBI)NCT07735741

Phase 2

A Phase II Prospective Study Evaluating Selective Depletion of CD45RA+ (Naïve) T Cells (TND) From Peripheral Blood Stem Cell (PBSC) Grafts for Prevention of Graft Versus Host Disease (GVHD) in Non-Malignant Diseases (NMDs)

This phase II trial investigates how well a naive T cell depleted graft work for the reduction of graft versus host disease in patients with non-malignant dise…

Bone Marrow FailureHemoglobinopathiesPrimary Immune Deficiency (PID)+4 more

Estimated

~$10 – $6,250

Fred Hutchinson Cancer CenterNCT07660783

Phase 2

Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)

This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradia…

Common Variable Immunodeficiency (CVID)Primary Immune Regulatory DisorderImmune Dysregulation+12 more

Estimated

~$10 – $7,500

Paul SzabolcsNCT07284641

Natural History Study for Genetic Diseases of Allergic Inflammation and Immune Dysregulation

This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic infl…

Immune DeficiencyImmune Dysregulation DisorderAllergic Inflammation

Estimated

~$10 – $750

Columbia UniversityNCT05584488

Phase 4

Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use (MET-IH)

This randomized clinical trial (RCT) evaluates whether metformin can reduce systemic inflammation and improve immune function in individuals with a history of …

Systemic InflammationImmune DysregulationInjection Drug Use+1 more

Estimated

~$10 – $6,250

University of Alabama at BirminghamNCT06829238