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64 recruiting studies matching your filters

Prospective Study of the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Background: Pyrimidine and purine metabolism disorders (DPPMs) affect how the body metabolizes chemicals called pyrimidines and purines. DPPMs can cause dysfu…

AMPD3, OMIM*102772, AMP Deaminase DeficiencyAK1, OMIM *103000, Adenylate Kinase DeficiencyAMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency+25 more

Estimated

~$10 – $675

National Human Genome Research Institute (NHGRI)NCT06092346

Phase 1

Phase I Dose Escalation Study of the Use of ACU-D1, a Topical Proteasome Inhibitor in HPV Associated Vulvar and Perianal Lesions in People With HIV

The goal of this study is to test the maximum tolerated dose of ACU-D1 in HIV-positive people with HPV-associated vulvar and perianal lesions. The main questio…

Human Papilloma VirusHuman Immunodeficiency VirusAnal Intraepithelial Neoplasia+1 more

Estimated

~$10 – $6,250

Emory UniversityNCT06233331

Phase 2

Psilocybin Recovery Intervention for Stopping Methamphetamine Use

The goal of this clinical trial is to learn whether it is possible to use psilocybin in combination with motivational support therapy to treat moderate-to-seve…

Methamphetamine Use DisorderHuman Immunodeficiency Virus (HIV)

Estimated

~$10 – $7,500

Nicky Mehtani, MD, MPHNCT07756736

Phase 2

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of Resmetirom for the Treatment of Metabolic Dysfunction- Associated Steatotic Liver Disease (MASLD) in People Living With Human Immunodeficiency Virus (HIV)

The purpose of this research study is to test the safety and effectiveness of the study drug, resmetirom, in participants with MASLD and HIV. This is a researc…

MASLD - Metabolic Dysfunction-Associated Steatotic Liver DiseaseHIV (Human Immunodeficiency Virus)

Estimated

~$10 – $8,750

Naga P. ChalasaniNCT07143968

Phase 4

Vaginal Estradiol Versus Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms, Dysbiosis and Markers of Latency Reversal in Menopausal Women Living With HIV

This is a research study about the effects of vaginal estradiol compared to moisturizer on vaginal symptoms of menopause and the microbiome in women with HIV. …

Menopausal ComplaintsVaginal AtrophyGenitourinary Symptoms+4 more

Estimated

~$10 – $6,250

Albert Einstein College of MedicineNCT07526948

Phase 2

Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

There is no standard of care therapy for patients with granulomatous-lymphocytic interstitial lung disease (GLILD) seen in common variable immunodeficiency (CV…

Interstitial Lung DiseaseCommon Variable Immunodeficiency

Estimated

~$10 – $5,625

Children's Hospital Medical Center, CincinnatiNCT04925375

Observational

A Gender-Affirming Stigma Intervention to Improve Substance Misuse and HIV Risk Among Transgender Women

This study is testing a new mutual-help group called "the TLC program" for transgender adults who use substances or are recently in recovery. The TLC Program i…

Substance AbuseSubstance AddictionSubstance Use Disorder (SUD)+2 more

Estimated

~$10 – $6,250

Illinois Institute of TechnologyNCT06880705

Phase 2

A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome

Background: Allogeneic hematopoietic stem cell transplant involves taking blood stem cells from a donor and giving them to a recipient. The transplants are us…

ImmunodeficiencyHematopoietic Stem Cell Transplantation

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT05027945

Phase 1

Lenacapavir Intensification to Disrupt HIV Reservoirs in Virologically Suppressed People With HIV Receiving Antiretroviral Therapy

Background: Antiretroviral viral therapy (ART) allows people with human immunodeficiency (HIV) to live long, healthy lives. But ART is not a cure. HIV can rem…

Human Immunodeficiency Virus

Estimated

~$10 – $5,625

National Institute of Allergy and Infectious Diseases (NIAID)NCT06819176

Phase 2

A Phase 2 Clinical Study to Evaluate the Pharmacokinetics, Safety, and Efficacy of Doravirine and Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate in Participants With HIV-1, Who Are 4 Weeks to Less Than 12 Years of Age and Weigh Less Than 45 kg

This is a single-group, open-label, multi-site study in pediatric participants with human immunodeficiency virus type 1 (HIV-1) infection, aged 4 weeks to \<12…

Human Immunodeficiency Virus (HIV) Infection

Estimated

~$10 – $8,750

Merck Sharp & Dohme LLCNCT04375800

Phase 2

Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)

This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradia…

Common Variable Immunodeficiency (CVID)Primary Immune Regulatory DisorderImmune Dysregulation+12 more

Estimated

~$10 – $7,500

Paul SzabolcsNCT07284641

Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV (SPISE)

This observational research study is studying how substance use impacts scarring and inflammation of the heart. This study involves one study visit for a cardi…

HIV (Human Immunodeficiency Virus)

Estimated

~$10 – $675

University of California, San FranciscoNCT07461350