This phase II pilot trial studies how well pembrolizumab works in treating leukoplakia. Monoclonal antibodies, such as pembrolizumab, may interfere with the ab…

ErythroleukoplakiaLeukoplakiaVerrucous Oral Leukoplakia

~Estimated

~$10 – $6,250

Jonsson Comprehensive Cancer CenterNCT03603223

Phase 2

Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia

This is a Phase IIa oral cavity leukoplakia study of pioglitazone 15mg and metformin 500mg BID for 12 weeks. The primary objective is to determine the clinical…

Oral Leukoplakia

~Estimated

~$10 – $6,250

University of MinnesotaNCT05727761

Phase 1

Topical Imiquimod for the Treatment of Oral Dysplastic Lesions With Clinical and Histologic Assessments

The goal of this clinical trial is to determine the effectiveness of imiquimod in treating oral dysplasia in adult patients. Imiquimod 5% cream could be a safe…

Oral DysplasiaLeukoplakia OralLeukoplakia

~Estimated

~$10 – $6,250

University of Southern CaliforniaNCT07210775