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6 recruiting studies matching your filters

A Phase 1/2, First-in-Human Safety and Proof-of-Concept Study to Evaluate EGEN-5784 Porcine Liver (Drug Product) in Combination With the Metra® Extra-Corporeal Liver Cross-Circulation System in Participants With Acute-on-Chronic Liver Failure

This is a Phase 1/2, first-in-human (FIH) safety, proof-of-concept, two-part study of the genetically-engineered EGEN-5784 liver in combination with the metra®…

Acute on Chronic Liver Failure (ACLF)Hepatic Encephalopathy (HE)

Estimated

~$10 – $8,750

eGenesis, INCNCT07429838

Phase 2

Effects of Empagliflozin on Natriuresis and Volume Overload in Patients With Cirrhosis and Ascites

A proof-of-concept placebo-controlled trial to explore the acute and 14-day effects of empagliflozin on natriuresis and total body water in patients with cirrh…

CirrhosisLiver Failure

Estimated

~$10 – $6,250

Yale UniversityNCT05726032

Phase 1

A Phase 1-2 Prospective Study to Evaluate the Safety and Feasibility of Total Lymphoid Irradiation (TLI) and Anti-Thymocyte Globulin (ATG) in Liver Transplantation Recipients to Induce Immune Tolerance

The unmet medical need in solid organ transplantation is to eliminate the lifelong requirement of powerful immune suppression drug combinations with their atte…

Liver Failure

Estimated

~$10 – $6,250

Stanford UniversityNCT07634562

Phase 1

A Phase 1, Open-Label, Dose-Escalation Study to Determine an Appropriate Starting Dose of Sacituzumab Govitecan in Subjects With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

The goals of this clinical study are to learn more about the safety and dosing of the study drug, sacituzumab govitecan-hziy, in participants with solid tumors…

Advanced or Metastatic Solid TumorLiver Failure

Estimated

~$10 – $7,500

Gilead SciencesNCT04617522

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure (ACLF): iNdications and outComEs

Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker rec…

Liver DiseasesLiver CirrhosisAcute-On-Chronic Liver Failure+1 more

Estimated

~$10 – $750

European Foundation for Study of Chronic Liver FailureNCT04613921

Phase 1

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) trial is a single center prospective adaptive phase 1b clinical trial in patients who ar…

Liver DiseasesLiver FailureCirrhosis, Liver

Estimated

~$10 – $6,250

University of ChicagoNCT06871111