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6 recruiting studies matching your filters

Randomized Phase 2 Trial of Ruxolitinib in Combination With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma.

The purpose of this research is to test the safety and effectiveness of the investigational drug ruxolitinib when it is combined with standard of care treatmen…

GlioblastomaBrain CancerGlioblastoma Multiforme+4 more

Estimated

~$10 – $7,500

Baptist Health South FloridaNCT06991101

Phase 3

A Randomized Phase III Study Comparing Temporally-Modulated Pulsed Radiation Therapy (TMPRT) Versus Standard Radiation Therapy With Temozolomide for Adults With Newly Diagnosed MGMT-Unmethylated Glioblastoma

This phase III trial compares temporally-modulated pulsed radiation therapy versus standard radiation therapy in treating patients with newly diagnosed, IDH wi…

Glioblastoma, IDH-WildtypeMGMT-Unmethylated Glioblastoma

Estimated

~$10 – $7,500

NRG OncologyNCT07452458

Phase 1

Safety and Feasibility of First-line Avutometinib and Defactinib in Patients With Newly Diagnosed High-grade Gliomas

This clinical trial is designed with two treatment stages: Stage 1: one cycle of study drug treatment prior to initiation of first-line standard radiation in a…

MGMT-unmethylated Glioblastoma (GBM)IDH Wildtype Glioblastoma

Estimated

~$10 – $6,250

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsNCT07778602

Phase 1

Phase 1 Study of Autologous Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13R alpha2 CAR (E-SYNC) T Cells in Adult Participants With EGFRvIII+ Glioblastoma

This phase I trial tests the safety, side effects, and best dose of E-SYNC chimeric antigen receptor (CAR) T cells after lymphodepleting chemotherapy in treati…

EGFR Gene MutationGlioblastomaMGMT-Unmethylated Glioblastoma+1 more

Estimated

~$10 – $7,500

Hideho Okada, MD, PhDNCT06186401

Phase 2

A Multi-Arm, Open Label, Phase II Trial of WP1066 and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

This phase II trial tests how well the combination of WP1066 and radiation therapy works in treating newly diagnosed glioblastoma. Glioblastoma is difficult to…

Glioblastoma, IDH-WildtypeMGMT-Unmethylated Glioblastoma

Estimated

~$10 – $6,250

Northwestern UniversityNCT05879250

Phase 1

A Phase I/IIa Study to Evaluate the Efficacy of DB107-RRV (Formerly Toca511), Administered to Subjects at Time of Resection and Intravenously Thereafter, in Combination With DB107-FC (Formerly Toca FC) and Radiation Therapy or DB107-FC, Temozolomide (TMZ) and Radiation Therapy in Patients With Newly Diagnosed High Grade Glioma

This is a multicenter, open-label study of DB107-RRV (formerly Toca 511) and DB107-FC (formerly Toca FC) when administered following surgical resection in newl…

High Grade GliomaMGMT-Unmethylated GlioblastomaMGMT-Methylated Glioblastoma

Estimated

~$10 – $5,625

University of California, San FranciscoNCT06504381