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Phase 1
Immunotherapy For Adults With GPC3-Positive Solid Tumors Using Interleukin-15 And -21 Armored Glypican-3-Specific Chimeric Antigen Receptor Expressing Autologous T Cells
The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancers. This research study combines two different way…
HepatoblastomaHepatocellular CarcinomaWilms Tumor+5 more
Baylor College of MedicineNCT06198296
Phase 1
Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressing Autologous T Cells as an Immunotherapy for Children With Solid Tumors (CARE)
Patients may be considered if the cancer has come back, has not gone away after standard treatment or the patient cannot receive standard treatment. This resea…
Liver CancerRhabdomyosarcomaMalignant Rhabdoid Tumor+3 more
Baylor College of MedicineNCT04715191
Phase 1
Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells
This Phase 1, open-label, non-randomized study will enroll pediatric and young adult subjects with relapsed or refractory non-central nervous system (CNS) mali…
Solid Tumor (Excluding CNS)Liver Cell CarcinomaMalignant Rhabdoid Tumor+7 more
Seattle Children's HospitalNCT07148050