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7 recruiting studies matching your filters

PNOC044: Liothyronine (L-T3) in Combination With Bevacizumab, Irinotecan and Temozolomide (BIT) for Progressive or Relapsed Medulloblastoma (Cohort 1) or as Monotherapy for Medulloblastoma With Minimal Residual Disease (Cohort 2)

This is a Phase 1/Phase 2 study assessing liothyronine (L-T3) immunotherapy and in combination with standard chemotherapy (bevacizumab, irinotecan and temozolo…

MedulloblastomaMedulloblastoma, ChildhoodMedulloblastoma Recurrent

Estimated

~$10 – $7,500

Sabine Mueller, MD, PhDNCT07346157

Observational

Cognitive Rehabilitation for Survivors of Childhood Medulloblastoma Using Real Time Hemodynamic Neurofeedback

This study will evaluate a new way to help childhood medulloblastoma survivors improve their thinking and memory skills. Many survivors experience long term ch…

Medulloblastoma, ChildhoodSurvivorship

Estimated

~$10 – $6,250

St. Jude Children's Research HospitalNCT07830134

Phase 1

A Phase 1/1b Study of Autologous b7-h3 Chimeric Antigen Receptor t Cells (b7-h3.cd28z.Cart) in Children and Young Adults With Recurrent or Progressive Cns Neoplasms Expressing b7-h3 Target

The purpose of this research study is to test the safety and effectiveness of a cell therapy at different doses for children and young adults with recurrent or…

Central Nervous System NeoplasmsBrain TumorBrain Tumor, Recurrent+11 more

Estimated

~$10 – $7,500

Robbie MajznerNCT07390539

Registry Study of Children and Adults Patients With Relapsed, Refractory, or Progressive Sonic Hedgehog Medulloblastoma Harboring U1 Mutation

The purpose of this study is to create a biobank for patients diagnosed with Sonic Hedgehog Medulloblastoma at Baylor College of Medicine/Texas Children's Canc…

Medulloblastoma RecurrentMedulloblastoma, Childhood, RecurrentMedulloblastoma, SHH-activated and TP53 Mutant+1 more

Estimated

~$10 – $1,125

Mohammad H. Abu ArjaNCT07242963

Observational

A Pilot Feasibility and Efficacy (Phase 2) Trial of Real Time Drug Screening and Genomic Testing to Determine an Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma

The current study will use a new treatment approach based on the molecular characteristics of each participant's tumor. The study will test the feasibility in …

MedulloblastomaMedulloblastoma, ChildhoodMedulloblastoma Recurrent+3 more

Estimated

~$10 – $5,625

University of California, San FranciscoNCT05057702

Phase 1

Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)

This is an open-label phase 1 safety and feasibility study that will employ multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against prote…

Medulloblastoma, ChildhoodAtypical Teratoid/Rhabdoid Tumor of CNSEmbryonal Tumor With Multilayered Rosettes+3 more

Estimated

~$10 – $5,625

Children's National Research InstituteNCT06193759

Phase 1

Phase 1 Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4+ and CD8+ T cells lentivirally transduced to express …

Central Nervous System TumorDiffuse Intrinsic Pontine GliomaDiffuse Midline Glioma+8 more

Estimated

~$10 – $6,250

Seattle Children's HospitalNCT04185038