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28 recruiting studies matching your filters
Phase 1
Atovaquone Combined With Radiation in Children With Malignant Brain Tumors
The goal of this interventional study is to Assess the safety and tolerability of atovaquone in combination with standard radiation therapy (RT) for the treatm…
High-grade GliomaMedulloblastomaDiffuse Intrinsic Pontine Glioma+1 more
Emory UniversityNCT06624371
Phase 1
Repurposing Ibrutinib for Chemo-Immunotherapy in a Phase 1b Study of Ibrutinib With Indoximod Plus Metronomic Cyclophosphamide and Etoposide for Pediatric Patients With Brain Cancer
Recent lab-based discoveries suggest that IDO (indoleamine 2,3-dioxygenase) and BTK (Bruton's tyrosine Kinase) form a closely linked metabolic checkpoint in tu…
EpendymomaMedulloblastomaGlioblastoma+1 more
Theodore S. JohnsonNCT05106296
Phase 1
Phase I/II Trial of PLX038 in Primary Central Nervous System Tumors With and Without MYC or MYCN Amplifications
Background: About 90,000 new cases of brain and spinal cord tumors are diagnosed annually in the United States. Most of these tumors are benign; however, abou…
GliomaMedulloblastomaEpendymoma+1 more
National Cancer Institute (NCI)NCT06161519
Phase 2
SJiMB21: Phase 2 Study of Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma
This is a multi-center, multinational phase 2 trial that aims to explore the use of molecular and clinical risk-directed therapy in treatment of children 0-4.9…
Medulloblastoma
St. Jude Children's Research HospitalNCT05535166