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119 recruiting studies matching your filters

Prospective Evaluation of Quality of Life in Patients With Breast Cancer Brain Metastases and Leptomeningeal Disease

Central nervous system (CNS) metastases including breast cancer brain metastases (BCBMs) and leptomeningeal disease (LMD) are common affecting up to 30% of pat…

Breast Cancer, Quality of LifeBreast Cancer, MetastaticBreast Cancer, Metastatic Breast Cancer+2 more

Estimated

~$10 – $675

Actual pay is set by the research site.

University of California, San FranciscoNCT07659652

Phase 1

A Phase 1/2, Open-label Study of Oral S241656 (BDTX-4933) as Monotherapy and in Combination With Other Anti-Cancer Therapies in Patients With KRAS, BRAF and Other Selected RAS/MAPK Mutation-Positive Malignancies

BDTX-4933-101 is a first-in-human, open-label, Phase 1/2 dose escalation, dose optimization and expansion study designed to evaluate the safety and tolerabilit…

Non-small Cell Lung CancerHistiocytic NeoplasmHistiocytosis+29 more

Estimated

~$150 – $4,500

Phase 2

IIT2022-05-Sankar-BELIEVE: Phase II Study of Bevacizumab in Combination With Chemoimmunotherapy and Maintenance Atezolizumab in Patients With Extensive Stage Small Cell Lung Cancer and Liver Metastases

This clinical trial aims to assess whether the addition of bevacizumab to atezolizumab and chemotherapy can improve response to treatment and progression-free …

Extensive-stage Small-cell Lung CancerLiver Metastases

Estimated

~$75 – $3,000

Actual pay is set by the research site.

Kamya SankarNCT05588388

Observational

Pressure-Enabled Selective SIR-Sphere Uptake for Radiation Efficacy (PRESSURE): A Prospective Randomized Clinical Trial of End Hole vs. Pressure-Modulated Delivery of Y-90 Resin Microspheres to Liver Metastases.

Patients with liver metastases undergoing planning arteriography for Y-90 administration by interventional radiology will be screened for study enrollment. If …

Liver MetastasesTumor

Estimated

~$10 – $750

Actual pay is set by the research site.

Stanford UniversityNCT07791446

Phase 2

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

This is a randomized, phase II trial comparing staged stereotactic radiosurgery (SSRS) versus fractionated stereotactic radiotherapy (FSRT) in patients with la…

Brain MetastasesCancer (With CNS Involvement)

Estimated

~$75 – $2,000

Actual pay is set by the research site.

Medical University of South CarolinaNCT07227610

Phase 1

A Phase I Study to Assess Safety and Feasibility of IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases From Primary Cancers (IMPACT-MET)

This is a Phase I Study evaluating the safety and feasibility of IL-8 receptor-modified patient-derived activated CD70 CAR T cells in adult patients with brain…

Brain Metastases

Estimated

~$150 – $3,000

Actual pay is set by the research site.

University of FloridaNCT07569263

Phase 1

DURABLE: Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and rEarrangements

This study will consist of a Phase 1b and Phase 2 portion. The Phase 1b portion will enroll first followed by the Phase 2 portion. Each cycle of treatment = 28…

Lung CancerNSCLCBrain Metastases

Estimated

~$150 – $4,500

Actual pay is set by the research site.

Joshua PalmerNCT05987644

Phase 2

Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone Metastases

The investigators hypothesize that with dose escalation to 40-50 Gy in ten fractions, the complete pain response rate at one month can be increased to 40-50% i…

Neoplasm MetastasesMetastases, Neoplasm

Estimated

~$75 – $2,000

Actual pay is set by the research site.

Rutgers, The State University of New JerseyNCT05419518

Phase 4

Low Molecular Weight Heparin Versus Aspirin for Venous Thromboembolism Prophylaxis in Orthopaedic Oncology

Aspirin and low molecular weight heparin (LMWH) are both commonly employed pharmacologic methods of venous thromboembolism (VTE) prophylaxis after orthopaedic …

SarcomaSoft Tissue SarcomaBone Sarcoma+4 more

Estimated

~$25 – $1,000

Actual pay is set by the research site.

Massachusetts General HospitalNCT03244020

Phase 1

Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM): A Multi-cohort Platform Trial of Adaptive Radiotherapy Approaches in Multiple Cancer Types

To characterize feasibility, safety, and/or preliminary efficacy of personalized strategies to adapt standard radiotherapy treatments to individual patient res…

Small Cell Lung Cancer Extensive StageBrain MetastasesSolid Tumor, Adult+3 more

Estimated

~$150 – $3,000

Actual pay is set by the research site.

University of Texas Southwestern Medical CenterNCT07139990

Phase 1

A Phase 1/1b Study of IAM1363 in Participants With Advanced Cancers Harboring HER2 Alterations

This is a Phase 1/1b open-label, multi-center dose escalation and dose optimization study designed to evaluate the safety and preliminary efficacy of IAM1363 i…

HER2 Mutation-Related TumorsHER2HER2-positive Breast Cancer+10 more

Estimated

~$150 – $4,200

Actual pay is set by the research site.

Iambic Therapeutics, IncNCT06253871

Abductor Reattachment Methods in Proximal Femur Replacements: What is the Best Method?

The purpose of this study is to assess the functional outcomes in patients undergoing proximal femur resection and reconstruction with an endoprosthesis, based…

SarcomaBone MetastasesProximal Femur Replacement

Estimated

~$10 – $750

Actual pay is set by the research site.

Duke UniversityNCT03261544