Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.…

Mitochondrial EnergeticsDietary NitrateDisuse Atrophy (Muscle) of Lower Leg

~Estimated

~$10 – $6,250

Indiana UniversityNCT07161973

Phase 2

Randomized Cross-over Trial of Sodium Bicarbonate on Muscle Mitochondrial Energetics and Physical Endurance in Chronic Kidney Disease and Metabolic Acidosis

Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitoch…

Chronic Kidney DiseasesMetabolic AcidosisFatigue+4 more

~Estimated

~$10 – $6,250

University of California, DavisNCT04984226