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Phase 1
Phase 1 Trial of Thiotepa-based Conditioning Regimen With De-escalated Post-graft Cyclophosphamide for Allogeneic Stem Cell Transplantation in Hematologic Malignancies
This phase 1 trial will investigate the safety and effectiveness of Thiotepa, Busulfan, and Fludarabine (TBF) conditioning regimen with post-transplant cycloph…
Acute Lymphocytic Leukemia (ALL)Acute Myeloid Leukemia (AML)Acute Leukemia+2 more
Sawa Ito, MDNCT07565220
Phase 1
A Phase 1B/2A Trial of NADUNOLIMAB in Combination With Azacitidine (With/Without Venetoclax) in Patients With Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML)
To evaluate safety and determine the recommended Phase II dose (RP2D). We hypothesize that targeting leukemia stem/progenitor cells (LSCs) with nadunolimab (IL…
Myelodysplastic Syndrome(MDS)Acute Myelogenous Leukemia (AML)
M.D. Anderson Cancer CenterNCT06548230