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3 recruiting studies matching your filters
Phase 1
A Pilot/Phase 1 Study of Immunosuppression-free Regulatory T-cell Graft-engineered Haploidentical Hematopoietic Cell Transplantation in Relapsed/Refractory and Ultra-High-risk AML/MDS
This research study is evaluating the safety and efficacy of the IS-free Treg-cell graft-engineered haplo transplant method in people with relapsed/refractory …
Stem Cell Transplant ComplicationsGraft Vs Host DiseaseMyeloid Leukemia, Acute+2 more
Dana-Farber Cancer InstituteNCT04678401
Phase 1
A Phase I Study of Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Other Hematologic Malignancies
Background: Blood cancers (such as leukemias) can be hard to treat, especially if they have mutations in the TP53 or RAS genes. These mutations can cause the …
Malignancy, HematologicNeoplasms, HematologicNeoplasms, Hematopoietic+8 more
National Cancer Institute (NCI)NCT06904066
Observational
A Decisional Intervention for Older Adults With Acute Myeloid Leukemia and Their Caregivers
This is a multicenter randomized controlled trial that assesses the efficacy of a decisional intervention \[University of Rochester-Geriatric Oncology assessme…
OncologyMyeloid Leukemia, AcuteCancer
University of RochesterNCT06697600