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Phase 2
Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease: A Prospective, Phase II Study.
This study is a pilot, phase II, open-label study of the angiotensin II receptor blocker, losartan, in patients with Sickle Cell Disease (SCD) 6 years or older…
Sickle Cell DiseaseDiffuse Myocardial Fibrosis
Children's Hospital Medical Center, CincinnatiNCT05012631
Phase 4
High Relaxivity Contrast Agent for Cardiac MR in the Myocardial Scar Assessment
Elucirem (Gadopiclenol) is a new macrocyclic gadolinium-based contrast agent (GBCA) with high relaxivity indicated for use in adults and children aged 2 years …
Myocardial Fibrosis
Johns Hopkins UniversityNCT05954559
Phase 1
Phase IA and IB Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia
The purpose of this study is to test the safety and preliminary efficacy of AAVrh.10hFXN to treat the cardiomyopathy associated with Friedreich's ataxia (FA). …
Friedreich AtaxiaCardiomyopathiesCardiac Hypertrophy+1 more
Weill Medical College of Cornell UniversityNCT05302271