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13 recruiting studies matching your filters

A Multicenter, Randomized, Controlled Study to Evaluate the Safety and Effectiveness of a Bioresorbable Nasal Dressing Containing Mometasone Furoate Compared to a Steroid-eluting Sinus Stent

The primary objective of the study is to evaluate the safety and effectiveness of OCEAN as an adjunct aid in wound healing after nasal/sinus surgery and to dem…

Chronic Rhinosinusitis (CRS)Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps

Estimated

~$10 – $1,125

Actual pay is set by the research site.

Polyganics BVNCT07286201

Phase 2

A Single-arm Extension Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Lunsekimig in Adult Participants With Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Clinical Study

This is a single-arm extension study to investigate the long-term safety, tolerability, and efficacy of lunsekimig in adult participants with inadequately cont…

Chronic Rhinosinusitis With Nasal Polyps

Estimated

~$75 – $3,000

Actual pay is set by the research site.

SanofiNCT06914908

Phase 3

A Randomized, Double-blind, Parallel Group Phase 3 Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) (PERSIST CRSwNP-2)

The aim of this study is to assess the efficacy and safety of GSK5784283 administered as add-on maintenance therapy to participants with CRSwNP.

Nasal Polyps

Estimated

~$50 – $2,250

Actual pay is set by the research site.

GlaxoSmithKlineNCT07782957

Phase 4

Interleukin-4Ralpha Blockade by Dupilumab Decreases Staphylococcus Aureus Colonization and Increases Microbial Diversity in Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)

Hypothesis: The investigators hypothesize that in patients with CRSwNP who demonstrate sinus colonization with staphylococcus aureus, the administration of dup…

Nasal PolypsStaphylococcus Aureus

Estimated

~$25 – $1,000

Actual pay is set by the research site.

University of VirginiaNCT05094570

Observational

Active vs. Passive Virtual Reality for Reducing Pain and Anxiety During Office-based ENT Procedures

The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office…

PainAnxietyChronic Rhinosinusitis (CRS)+5 more

Estimated

~$10 – $750

Actual pay is set by the research site.

Cedars-Sinai Medical CenterNCT07599826

Olfactory Cleft Obstruction and Electrophysiological Olfactory Bulb Generated Beta Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.

The goal of this observational study is to learn what can predict the return of the sense of smell in patients with chronic rhinosinusitis with nasal polyps be…

Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP)Smell Loss

Estimated

~$10 – $750

Actual pay is set by the research site.

Northwestern UniversityNCT06892704

Phase 4

SMART Use of Biologics in Chronic Rhinosinusitis With Nasal Polyposis

The prevalence of Chronic Sinusitis with Nasal Polyps (CRSwNP) in the United States is estimated at roughly 4%, which equates to over 13 million Americans. Unt…

Chronic SinusitisNasal Polyps

Estimated

~$25 – $1,000

Actual pay is set by the research site.

Medical University of South CarolinaNCT06824649

Phase 3

A 12-Week Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of Intranasal Administration of 186 mcg of OPN-375 Twice a Day (BID) in Adolescent Subjects With Chronic Rhinosinusitis Without Nasal Polyps

This is a 12-Week randomized, double-blind, placebo-controlled, parallel-group, multicenter study evaluating the efficacy and safety of intranasal administrati…

Chronic Rhinosinusitis Without Nasal Polyps

Estimated

~$50 – $2,100

Actual pay is set by the research site.

Optinose US Inc.NCT06850805

CRS Questionnaire Validation Project

The 'CRS validation project' consists of a joint effort of 32 medical centers in Europe, the USA, and South Africa to carry out the validation of 2 novel quest…

Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps

Estimated

~$10 – $1,125

Actual pay is set by the research site.

The European Forum for Research and Education in Allergy and Airway DiseasesNCT06970977

Phase 3

A Randomized, Double-blind, Parallel Group Phase 3 Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) (PERSIST CRSwNP-1)

The aim of this study is to assess the efficacy and safety of GSK5784283 administered as add-on maintenance therapy to participants with CRSwNP.

Nasal Polyps

Estimated

~$50 – $2,250

Actual pay is set by the research site.

GlaxoSmithKlineNCT07782970

Phase 3

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Lebrikizumab/LY3650150 in Participants With Chronic Rhinosinusitis With Nasal Polyps on Background Intranasal Corticosteroids

The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab in participants with chronic rhinosinusitis and nasal polyps treated with…

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Estimated

~$50 – $2,250

Actual pay is set by the research site.

Eli Lilly and CompanyNCT06338995

Observational

3D Printing for Topical Nasal Corticosteroid Irrigations: a Randomized Clinical Trial.

Three-dimensional (3D) printing has been an emerging technology with uses in a wide array of fields. This research aims to use 3D printing as a tool to provide…

Chronic Rhinosinusitis With Nasal PolypsChronic Rhinosinusitis Without Nasal Polyps

Estimated

~$10 – $750

Actual pay is set by the research site.

Ohio State UniversityNCT06118554