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7 recruiting studies matching your filters

A Phase 2 Randomized, Multicenter Study to Evaluate the Efficacy and Safety of Silevertinib, an Oral EGFR Inhibitor, in Combination With Temozolomide in Patients With Newly Diagnosed Glioblastoma With Unmethylated MGMT Promoter and EGFRvIII

The purpose of this study is to see if combining silevertinib with temozolomide after surgery and radiotherapy helps treat newly diagnosed glioblastoma (GBM) b…

Glioblastoma (GBM)Newly Diagnosed GlioblastomaGBM+4 more

Estimated

~$10 – $8,750

Black Diamond Therapeutics, Inc.NCT07326566

Observational

REMIND: An Investigator Initiated Study Testing the Feasibility of Maintenance Radiotherapy for Patients With Newly Diagnosed Glioblastoma

REMIND is a single-center feasibility study testing maintenance radiotherapy in adult patients with newly diagnosed glioblastoma. Participants will be consent…

GlioblastomaNewly Diagnosed GlioblastomaBrain Tumor

Estimated

~$10 – $6,250

University of MinnesotaNCT07831772

Phase 2

A Multi-Center, Randomized, Phase 2 Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab (GIANT)

GIANT is an open-label, multi-center, randomized, perioperative (neoadjuvant followed by adjuvant), phase 2 trial with a safety lead-in phase to investigate th…

Newly Diagnosed Glioblastoma

Estimated

~$10 – $6,250

Duke UniversityNCT06816927

Phase 1

A Phase 1 Study of Bispecific T Cell Engager (BRiTE) in Patients With Newly Diagnosed or Recurrent Glioblastoma

This Phase 1 study will assess the safety of a novel brain Bispecific T cell engager (BRiTE) in patients with newly diagnosed or recurrent World Health Organiz…

Newly Diagnosed GlioblastomaRecurrent Glioblastoma

Estimated

~$10 – $7,500

Mustafa Khasraw, MBChB, MD, FRCP, FRACPNCT04903795

Phase 1

A Phase I/II Study of an AAV-1 Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma

The goal of this clinical trial is to first define the Safety and Optimal Biological Dose (OBD) of study drug TGX-007 and to then further investigate the safet…

Glioblastoma (GBM)High Grade GliomasRecurrent Glioblastoma+1 more

Estimated

~$10 – $8,750

Trogenix ltdNCT07346144

Phase 1

A Phase 1 Study of Combination Drug Therapy Based on Personalized Cancer Stem Cell (CSC) High-Throughput Drug Screening (HTS) With Standard of Care for Newly Diagnosed Glioblastoma

Proposed treatment of subjects with newly diagnosed glioblastoma with novel personalized drug regimens identified to be effective in vitro using cancer stem ce…

Newly Diagnosed Glioblastoma

Estimated

~$10 – $6,250

Swedish Medical CenterNCT05380349

Phase 2

A Phase 2 Randomized Open-Label Pilot Study of Granulocyte Colony Stimulating Factor (G-CSF) to Preserve Brain Structure and Function Following Standard Chemoradiation in Patients With Newly Diagnosed MGMT-Methylated Glioblastoma

This research study involves the study of granulocyte colony stimulating factor (G-CSF) in patients with MGMT-methylated glioblastoma multiforme (GBM) that are…

MGMT-Methylated GlioblastomaGlioblastoma (GBM)Newly Diagnosed Glioblastoma Multiforme

Estimated

~$10 – $6,250

Massachusetts General HospitalNCT06649851