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7 recruiting studies matching your filters

Functional Connectivity Mechanisms of Opioid Abstinence

This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.

Drug Use DisorderOpioid DependenceOpioid-Related Disorders+2 more

Estimated

~$10 – $750

Yale UniversityNCT06651333

Phase 1

Measuring Acute Drug Demand in Humans

This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.

Opioid Use DisorderOpioid Dependence

Estimated

~$10 – $6,250

University of Maryland, BaltimoreNCT05829655

Phase 4

Better Options for Chronic Cancer Pain: a SMART Study

This proposal is relevant to the 240,000 cancer survivors who continue to use opioids long after they have successfully completed treatment for cancer at the V…

Chronic PainCancer SurvivorOpioid Dependence

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT06574009

Phase 4

A Single-institution, Parallel, Double-blinded, Randomized Study Assessing the Safety and Efficacy of Transdermal Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

Addictive full-agonist opioids, like oxycodone and hydrocodone, are often used to treat pain after surgery. However, these full-agonist opioids can be very add…

Pain, PostoperativeAnkle Fracture SurgeryOpioid Use Disorder+2 more

Estimated

~$10 – $7,500

Jenna-Leigh WilsonNCT06949826

Phase 1

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose (SAD) Study With Food-Effect Cohort to Assess the Safety, Tolerability, and Pharmacokinetics of Oral (R) VK4-116 in Healthy Volunteers

This first-in-human, randomized, double-blind, placebo-controlled, single ascending dose (SAD), phase I study is designed to assess the safety, tolerability an…

Opioid DependenceOpioid Use Disorder (OUD)

Estimated

~$10 – $5,625

National Institute on Drug Abuse (NIDA)NCT06808932

Phase 4

Houston Emergency Engagement System for Youths and Adolescents

The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive o…

Opioid-use DisorderOpioid DependenceOpioid Overdose+2 more

Estimated

~$10 – $6,250

The University of Texas Health Science Center, HoustonNCT04811014

Observational

Designing Intensive Primary Care Interventions to Improve Addiction Treatment for Medically and Socially Complex Patients: The "MOUD PLUS (MOUD+)" Study

The goal of this pilot clinical trial is to learn if a community informed designed program of addiction counseling with coordinated community peer navigator fo…

Opioid DependenceSubstance Abuse DisordersComplex Medical Patients+1 more

Estimated

~$10 – $6,250

Oregon Health and Science UniversityNCT06837662