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235 recruiting studies matching your filters

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study With a Separate Open-label Cohort to Evaluate the Efficacy and Safety of Brenipatide as Adjunctive Treatment to Transmucosal Buprenorphine With or Without Naloxone in Early Recovery of Participants With Opioid Use Disorder (RENEW-Op-1)

The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with b…

Opioid Use Disorder

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07420283

Observational

Teaching Health Promotion and Resilience in Varied Environments: a Peer-led Intervention Following Hospital Discharge

The purpose of the study is to develop an acceptable, feasible, and effective peer-led bundle of health resilience and promotion services to be delivered in th…

Opioid Use DisorderHarm ReductionHealth Promotion

Estimated

~$10 – $6,250

University of PennsylvaniaNCT06843213

Observational

A Randomized Clinical Trial of Telehealth Treatment for Opioid Use Disorders

This trial will assess effects of enrollment in a comprehensive telehealth platform, RecoveryPad (RP), in adults with moderate or severe opioid use disorder.

Opioid Use Disorder

Estimated

~$10 – $6,250

Yale UniversityNCT07362082

Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder

The objective of this study is to evaluate the impact of clinical decision support (CDS) in the form of an alert to identify patients who may be at risk of opi…

Medication AbuseHarm ReductionOpioid Use Disorder+1 more

Estimated

~$10 – $750

University of Colorado, DenverNCT06526286

Phase 3

Improving Pain and Functioning Using an Integrative Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

Chronic pain is common in individuals with opioid use disorder (OUD) and the first-line treatment, Medication for OUD (MOUD), does not address the considerable…

Opioid Use DisorderChronic Pain

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT07361432

Phase 1

A Phase I, Single-Center, Single-Blind, Placebo-Controlled, Dose-Escalation Study to Assess the Safety, Pharmacokinetics and Efficacy of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid Use Disorder

This study is examining the use of Tezampanel (TZP) for treatment of Opioid Withdrawal Syndrome (OWS) in participants with Opioid Use Disorder (OUD). Participa…

Opioid Use Disorder

Estimated

~$10 – $8,750

Proniras CorporationNCT06538558

Observational

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

This project continues our work with women in the Kentucky Women's Justice Community Overdose Innovation Network Phase II (WJCOIN-II) with the overall aim of r…

Overdose RiskOpioid Use DisorderStimulant Use Disorders

Estimated

~$10 – $7,500

Michele StatonNCT07179614

Observational

A Study to Train a Machine Learning Algorithm for an Evaluation of the Use of Biometric Data Captured at the Wrist for the Identification of Acute Opioid Use Events and the Quantification of Opioid Withdrawal in Opioid Dependent Individuals

To train a machine learning model/algorithm for an evaluation of the use of biometric data captured at the wrist for the identification of acute opioid use eve…

Treatment for Opioid Use Disorder

Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial: Implementation of Screening and Brief Intervention

The present study seeks to examine the implementation process of culturally tailoring screening and brief intervention for both chronic pain and opioid misuse/…

Opioid Use DisorderOpioid MisuseChronic Pain

Estimated

~$10 – $6,250

University of New MexicoNCT06565416

Phase 4

Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment - A Pragmatic Hybrid Effectiveness/Implementation Trial

The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based bup…

Opioid Use Disorder

Estimated

~$10 – $6,250

Yale UniversityNCT06323824

Observational

Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness: An RCT Examining Biopsychosocial Mechanisms

Homelessness severely affects health and well-being and is particularly negative for youth. Between 70-95% of youth experiencing homelessness (YEH) report prob…

Opioid Use DisorderDual DiagnosisHousing Problems+3 more

Estimated

~$10 – $6,250

Ohio State UniversityNCT06311838

Phase 1

Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder

The goal of this research study is to examine the endocannabinoid (eCB) function in vivo in individuals with opioid use disorder (OUD) by measuring cannabinoid…

Healthy ControlOpioid Use Disorder

Estimated

~$10 – $6,250

Yale UniversityNCT05683184