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235 recruiting studies matching your filters

Development of an Opioid Withdrawal Clinical Outcome Assessment Among Persons With Opioid Use Disorder

Withdrawal management strategies are currently the most utilized and ubiquitous intervention for opioid use disorder in the US, yet existing measures of opioid…

Opioid Use Disorder

Estimated

~$10 – $750

University of Maryland, BaltimoreNCT07094672

Observational

Randomized Control Trial Evaluating Postoperative Opioid Demands Following Hip Arthroscopy

This study will be a prospective, single-blinded, randomized controlled trial (RCT), investigating the influence of the number of opioid pills prescribed follo…

Opioid UsePainFemoral Acetabular Impingement+1 more

Estimated

~$10 – $6,250

Rush University Medical CenterNCT04094701

Phase 2

NIDA CTN-0152: Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder: A Pragmatic, Multi-site, Double-blind, Randomized, Placebo-controlled Trial (TAB)

The primary objective of this research study is to evaluate the effect of tirzepatide, relative to placebo, as an adjunct to BUP on retention, substance use, a…

Opioid Use DisorderOpioid Use Disorder, ModerateOpioid Use Disorder, Severe

Estimated

~$10 – $7,500

T. John Winhusen, PhDNCT06651177

Medications for Opioid Use Disorder Differentially Modulate Intrinsically Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment (MOUD)

Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep …

Opioid Use DisorderSleep Disturbance

Estimated

~$10 – $750

University of Alabama at BirminghamNCT06104280

Phase 4

Assessing Optimal Extended-Release Buprenorphine (XRB) Initiation Points in Jail

This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescription…

Opioid Use Disorder

Estimated

~$10 – $7,500

NYU Langone HealthNCT06051890

Functional Connectivity Mechanisms of Opioid Abstinence

This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.

Drug Use DisorderOpioid DependenceOpioid-Related Disorders+2 more

Estimated

~$10 – $750

Yale UniversityNCT06651333

Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy

This study will be a 12-month prospective, genotype-blinded longitudinal observational study with current standard of clinical care. This study will enroll 100…

Opioid Use DisorderPregnancy Related

Estimated

~$10 – $1,125

Ilana HullNCT05942313

Phase 4

Acceptability and Feasibility of Extended-Release Subcutaneous Buprenorphine on a Mobile Pharmacy Clinic: A Pilot Study

This exploratory project will assess the acceptability and feasibility of monthly extended-release subcutaneous buprenorphine (BRIXADI; XR-B) to treat opioid u…

Opioid Use Disorder

Estimated

~$10 – $6,250

Yale UniversityNCT07176351

Phase 3

Safety and Efficacy of High Dose Buprenorphine Induction in Fentanyl Positive Emergency Department Patients

This project, involving two distinct clinical trials, tests whether induction to a higher than currently recommended buprenorphine (BUP) induction dose is safe…

Opioid Use Disorder

Estimated

~$10 – $6,250

Rutgers, The State University of New JerseyNCT05589181

Phase 1

A Pragmatic Remote Approach to Improve Transitions of Care and Retention in Opioid Use Disorder Treatment

This pilot study evaluates the feasibility, acceptability, and preliminary effectiveness of mailing buprenorphine to individuals with opioid use disorder (OUD)…

Opioid Use Disorder

Estimated

~$10 – $6,250

Medical University of South CarolinaNCT07421102

Observational

Autonomic Neural Blockade During Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial Evaluating Pain and Nausea After Bariatric Surgery

The purpose of this research is to evaluate if autonomic nerve block (ANB- blocking pain and nausea signals) decreases pain and anti-nausea medication requirem…

Bariatric Surgery CandidatePain, PostoperativeNausea and Vomiting, Postoperative+1 more

Estimated

~$10 – $7,500

Endeavor HealthNCT07104825

Observational

Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

To address both loneliness and engagement in perinatal and OUD care among perinatal women, the investigators plan to adapt an existing texting support chatbot,…

Perinatal Opioid Use DisorderOpioid Use Disorder

Estimated

~$10 – $6,250

University of PennsylvaniaNCT06969261