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4 recruiting studies matching your filters
Phase 1
A Phase I/Ib Study of Olaparib and ASTX727 in BRCA1/2- and HRD-mutated Tumors
This is a single center, phase I/Ib clinical trial evaluating the combination of the poly adenosine diphosphate-ribose polymerase (PARP) inhibitor olaparib wit…
BRCA1 MutationBRCA2 MutationBRCA Mutation+3 more
Pamela MunsterNCT06177171
Phase 1
SHARON: Study of Metastatic Cancers in Patients Using Autologous Stems Cells and Potentiated Redox Cycling to Overcome Drug Resistance to Nitrogen Mustard Derivatives
The clinical trial is a phase 1, single-arm trial that will evaluate the safety of the investigational treatment on metastatic pancreatic cancer and metastatic…
Pancreatic Adenocarcinoma MetastaticBRCA1 MutationBRCA2 Mutation+17 more
General Oncology, Inc.NCT04150042
Observational
Digital Technology to Enhance Access to and Effectiveness of Cancer Genetic Counseling: Effective Familial OutReach Via Tele-genetics (EfFORT) Trial & Supporting Test Result Interpretation and Variant Education (STRIVE) Trial
The purpose of this study is to examine the impact of new cancer genetic counseling models that aim to increase patient engagement with the genetics team. To d…
BRCA1 MutationPOLD1 Gene MutationCDKN2A Mutation+19 more
Memorial Sloan Kettering Cancer CenterNCT05420064
Phase 1
Combination Therapy of Niraparib and Irinotecan in Cancers With Mutations in DNA Repair Genes
The purpose of this phase 1 clinical trials is to determine whether niraparib (a Poly (ADP-ribose) polymerase inhibitor (PARPi)) can be safely combined with ir…
Metastatic Solid TumorBRCA1 MutationBRCA2 Mutation+2 more
University of California, San FranciscoNCT05694715