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An Observational Study to Assess Real-world Patient Characteristics, Clinical Course, and Treatment Patterns for Symptomatic Patients With Arrhythmogenic Cardiomyopathy (ACM) Due To a PlaKoPhilin-2 Pathogenic Variant (PKP2)
An observational study to assess real-world patient characteristics and clinical course of disease in participants with PKP2-ACM.
Arrhythmogenic CardiomyopathyPKP2-ACMPKP2-ARVC
Lexeo TherapeuticsNCT06976606
Phase 1
A Phase 1 Dose Escalation Trial Evaluating an Intravenously Administered Recombinant Adeno-Associated Virus Serotype rh.74 (AAVrh.74) Vector Containing the Human Plakophilin-2a (PKP2a) Coding Sequence (RP-A601; AAVrh.74-PKP2a) in Subjects With Arrhythmogenic Cardiomyopathy Arising From Pathogenic PKP2 Variants (PKP2-ACM)
This Phase 1 dose escalation trial will assess the safety and preliminary efficacy of a single dose intravenous infusion of RP-A601 in high-risk adult patients…
PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)
Rocket Pharmaceuticals Inc.NCT05885412