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Prevalence and Clinical Severity of Autoimmune Blistering Diseases
Pemphigus and bullous pemphigoid (BP) are severe autoimmune blistering diseases (AIBD) that pose a critical need for new therapeutic approaches. Clinical trial…
Pemphigus VulgarisPemphigus FoliaceusBullous Pemphigoid
University of PennsylvaniaNCT02753777
Phase 1
Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.
This study will evaluate the safety and activity of AB-101 in combination with rituximab in B-cell associated autoimmune diseases where rituximab is currently …
Rheumatoid ArthritisPemphigus VulgarisGranulomatosis With Polyangiitis+1 more
IRIS Research and Development, LLCNCT06581562
A Single-Site Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical resear…
Age-Related Macular DegenerationAllergiesAlpha-Gal Syndrome+44 more
Sanguine BiosciencesNCT05635266
Phase 1
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris
A phase 1/2, open-label, safety and dosing study of autologous CART cells (desmoglein 3 chimeric autoantibody receptor T cells \[DSG3-CAART\] or CD19-specific …
Pemphigus Vulgaris
Cabaletta BioNCT04422912