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3 recruiting studies matching your filters
Phase 1
A First-in-human Phase I Single-agent Dose-escalation, Food Effect and Dose Expansion Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
The primary objective of this Phase 1, open-label, dose-escalation, and exploratory study is to evaluate the safety and tolerability profile (establish the max…
Central Nervous System NeoplasmsGlioblastomaGliosarcoma, Adult+20 more
Jazz PharmaceuticalsNCT04541082
Phase 4
An Open Label, Multi-center Roll-over Study to Assess Long-term Effect in Pediatric Patients Treated With Tafinlar (Dabrafenib) and/or Mekinist (Trametinib)
A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.
Diffuse AstrocytomaAnaplastic AstrocytomaAstrocytoma+20 more
Novartis PharmaceuticalsNCT03975829
Observational
A Phase II Study of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma
Low-grade gliomas (LGGs) are the most common brain tumors in children, and a subset of these tumors are treated definitively with focal radiation therapy (RT).…
GliomaPilocytic AstrocytomaPilomyxoid Astrocytoma+4 more
St. Jude Children's Research HospitalNCT04065776