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National Institute of Allergy and Infectious Diseases (NIAID)NCT00246857

~$10 – $675

Primary Immune Deficiency DisordersMetabolic Disease

Study of TCR Alpha Beta T-Cell and CD19 B-Cell Depletion for Hematopoietic Cell Transplantation From Haploidentical Donors in the Treatment of Primary Immunodeficiency and Inherited Metabolic Disorders in Children

This research is being done to learn if a new type of haploidentical transplantation using TCR alpha beta and CD19 depleted stem cell graft from the donor is s…

Johns Hopkins All Children's HospitalNCT04414046

Bone Marrow FailureHemoglobinopathiesPrimary Immune Deficiency (PID)+4 more

A Phase II Prospective Study Evaluating Selective Depletion of CD45RA+ (Naïve) T Cells (TND) From Peripheral Blood Stem Cell (PBSC) Grafts for Prevention of Graft Versus Host Disease (GVHD) in Non-Malignant Diseases (NMDs)

This phase II trial investigates how well a naive T cell depleted graft work for the reduction of graft versus host disease in patients with non-malignant dise…

Fred Hutchinson Cancer CenterNCT07660783

Epstein-Barr Virus InfectionsPrimary Immune Deficiency Disorder

A Pilot Study in the Treatment of Refractory Epstein-Barr Virus (EBV) Infection With Related Donor EBV Cytotoxic T-Lymphocytes in Children, Adolescents and Young Adult Recipients

Related donor Epstein-Barr Virus (EBV) specific cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be admin…

New York Medical CollegeNCT03266653

Primary Immune Deficiency DisorderImmune Deficiency DiseaseBone Marrow Failure+7 more

Regenerative Medicine to Restore Hematopoiesis and Immune Function in Immunodeficiencies and Inherited Bone Marrow Failures

Phase II prospective trial to assess the rates of donor engraftment using reduced intensity conditioning (RIC) hematopoietic stem cell transplant (HSCT) and po…

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsNCT04232085

AdenovirusPrimary Immune Deficiency Disorder

A Pilot Study in the Treatment of Refractory Adenovirus (ADV) Infection With Related Donor ADV Cytotoxic T-Lymphocytes (ADV-CTLs)in Children, Adolescents and Young Adult Recipients

Related donor Adenovirus (ADV) specific cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered …

New York Medical CollegeNCT03266627

Biologics And Clinical Immunology Cohort at Sinai

The study team plans to establish a bioregistry of patients receiving biologic therapy as part of their standard treatment at the Mount Sinai Therapeutic Infus…

Immunological DiseaseAutoimmune DiseasesPrimary Immune Deficiency

Icahn School of Medicine at Mount SinaiNCT04784364

~$10 – $750

Cytomegalovirus InfectionsPrimary Immune Deficiency Disorder

A Pilot Study in the Treatment of Refractory Cytomegalovirus (CMV) Infections With Related Donor CMV Specific Cytotoxic T-cells (CTLs) in Children, Adolescents and Young Adult Recipients

CMV cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young a…

New York Medical CollegeNCT03266640

Phase 1

A Pilot Study in the Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs) in Children, Adolescents and Young Adult Recipients

BK cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be safe and effective in decreasing specific viral lo…

Viral InfectionPrimary Immune Deficiency Disorder