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18 recruiting studies matching your filters

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Phase 2

A Phase 2 Randomized, Double Blind, Placebo Controlled, Parallel Study Evaluating the Safety and Efficacy of LB P8 in Patients With Primary Sclerosing Cholangitis (PSC)

The study is designed to assess the safety and efficacy of LB-P8 in patients with primary sclerosing cholangitis.

Primary Sclerosing Cholangitis (PSC)

Estimated

~$10 – $8,750

LISCure BiosciencesNCT06699121

Phase 1

A 12-Month, Open-Label Study Evaluating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Siplizumab as Induction Therapy in Patients With Autoimmune Liver Diseases Undergoing Liver Transplantation (SET-SAIL)

There is a significant unmet need for safe and effective therapeutic approaches to prevent immune-mediated graft injury and its complications in liver transpla…

Autoimmune Liver DiseaseLiver Transplant DisorderAutoimmune Hepatitis+3 more

Estimated

~$10 – $7,500

Elizabeth C. VernaNCT06455280

A Resource of Blood and Other Biospecimens of Patients With Cholestatic Liver Disease and Unaffected Individuals

This study is a biobank of specimens and clinical data for use in current and future research to better understand the cholestatic liver diseases primary bilia…

Primary Sclerosing CholangitisPrimary Biliary CirrhosisCholangiocarcinoma+1 more

Estimated

~$10 – $750

Mayo ClinicNCT03445585

Phase 1

The Effect of Statin Therapy on Bile Acid Physiology and the Microbiome in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study

PSC is a liver disease that has no medical cure. Patients with PSC are at a greatly increased risk of cancer and infection. Additionally, many patients require…

Primary Sclerosing CholangitisInflammatory Bowel Diseases

Estimated

~$10 – $6,250

Stanford UniversityNCT05912387

Phase 2

A Study of Oral Hymecromone to Treat Adolescents and Adults With Primary Sclerosing Cholangitis(HAAPS Study).

Primary objective: To evaluate the efficacy of hymecromone plus standard of care compared with standard of care alone in the treatment of adolescents and adult…

Primary Sclerosing Cholangitis

Estimated

~$10 – $7,500

Aparna GoelNCT05295680

Phase 1

A Phase 1, Randomized, Placebo-Controlled, Double-Blind, Sponsor-Open Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-781 in Healthy Participants and a Single-Arm, Open-Label Evaluation in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis

The main aim of this study is to see if the drug TAK-781 is safe for healthy volunteers and for participants with PSC. The study will also look at how well par…

Healthy VolunteersPrimary Sclerosing Cholangitis

Estimated

~$10 – $7,500

TakedaNCT07229911