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OBSERVE: Biomarkers in Individuals at Risk for Prion Disease

We are doing this research to identify biomarkers in individuals who are at-risk for familial prion disease. We hope to use these biomarkers to predict timing …

CJD (Creutzfeldt Jakob Disease)Prion DiseasesGSS+2 more

Estimated

~$10 – $750

Actual pay is set by the research site.

Massachusetts General HospitalNCT05124392

Expanded Protocol for Teleneurology Assessment Program for Creutzfeldt-Jakob Disease (TAPCJD)

This observational study uses secure videoconference visits to follow people with Creuztzfeldt-Jakob disease (CJD) over time. The study collects information ab…

Creutzfeldt-Jakob Disease (CJD) | Prion Disease

Estimated

~$10 – $750

Actual pay is set by the research site.

University Hospitals Cleveland Medical CenterNCT07840547

PROSPECT: A Registry and Longitudinal Natural History Study of Individuals at Risk for Genetic Prion Disease

PROSPECT is a prospective observational registry and longitudinal natural history study of adults at risk for genetic prion disease.

Prion Diseases

Estimated

~$10 – $1,125

Actual pay is set by the research site.

Brian ApplebyNCT07732608

Phase 1

An Open-label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered PrP-siRNA in Adults Diagnosed With Symptomatic Prion Disease and in Pre-symptomatic Adults at Genetic Risk for Prion Disease.

The purpose of this trial is to evaluate safety, tolerability, pharmacokinetics and pharmacodynamic impact of PrP-siRNA in symptomatic prion disease patients a…

Prion Disease

Estimated

~$150 – $4,500

Actual pay is set by the research site.

Broad Institute of MIT and HarvardNCT07444580