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363 recruiting studies matching your filters

A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel Group Study to Evaluate the Efficacy and Safety of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease

The primary objective of this study is to evaluate the effect of 24-weeks of once daily treatment with TPIP versus placebo on exercise capacity in adults with …

Pulmonary HypertensionInterstitial Lung Disease

Estimated

~$10 – $8,750

Insmed IncorporatedNCT07179380

Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

Background: People with sickle cell disease (SCD) have problems with their heart, brain, kidneys, liver, and lungs as they age. These problems may improve aft…

Mortality in Sickle CellSickle Cell Cardiopulmonary ComplicationsSickle Cell Organ Damage+2 more

Estimated

~$10 – $675

National Heart, Lung, and Blood Institute (NHLBI)NCT05213572

Phase 3

A Phase III, Multi-center, Open-label, Randomised, Controlled Trial of Intravenous Obrixtamig in Combination With Carboplatin and Etoposide vs. Carboplatin and Etoposide as First-line Therapy in DLL3-positive Patients With Unresectable Locally Advanced or Metastatic Extrapulmonary Neuroendocrine Carcinomas

This study is open to adults with advanced extrapulmonary neuroendocrine cancer. The purpose of this study is to find out if a study medicine called obrixtamig…

Extrapulmonary Neuroendocrine Cancer (epNEC)

Estimated

~$10 – $7,500

Boehringer IngelheimNCT07544654

Phase 4

Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema (ONLY ONCE)

The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections aroun…

Pleural Infection BacterialPleural InfectionsPleural Infections and Inflammations+5 more

Estimated

~$10 – $6,250

University of North Carolina, Chapel HillNCT07095361

Phase 1

A Phase Ib/II, Open-label, Safety and Tolerability Trial of Obrixtamig in Combination With ZL-1310 in Patients With Poorly Differentiated NEC

This study is open to adults with advanced small cell lung cancer and other neuroendocrine cancers. The study has 2 parts. The purpose of Part 1 is to find a s…

Small Cell Lung CancerLarge Cell Neuroendocrine Lung CarcinomaExtrapulmonary Neuroendocrine Carcinoma of Small Cell Histology+1 more

Estimated

~$10 – $7,500

Boehringer IngelheimNCT07707895

Obtaining Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research

Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins a…

Endothelial DysfunctionInflammation in Cardiopulmonary and Vascular Disease StatesHealthy Volunteers

Estimated

~$10 – $675

National Institutes of Health Clinical Center (CC)NCT03253705

Phase 2

Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

This is a Phase II randomized, double-blind, placebo-controlled trial of sildenafil in men and women with Scleroderma with mildly elevated pulmonary pressures …

SclerodermaMildly Elevated Pulmonary Pressures

Estimated

~$10 – $6,250

Johns Hopkins UniversityNCT04797286

Cryptococcosis in Previously Healthy Adults

The protocol will be carried out in accordance with International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) G…

Cryptococcal InfectionCryptococcal PneumoniaPulmonary Cryptococcosis+2 more

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT00001352

Hormonal, Metabolic, and Signaling Interaction in Pulmonary Arterial Hypertension

Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences o…

Idiopathic Pulmonary Arterial HypertensionHeritable Pulmonary Arterial HypertensionScleroderma Associated Pulmonary Arterial Hypertension+1 more

Estimated

~$10 – $750

Vanderbilt University Medical CenterNCT01884051

Phase 2

A Phase 2, Multicenter, Randomized, Double-Blind, 52-week Study to Investigate the Efficacy and Safety of Brenipatide Compared With Placebo for the Treatment of Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

The main purpose of this study is to assess if different dose levels of Brenipatide are safe and work the way they are intended to work in participants with mo…

Pulmonary Disease, Chronic Obstructive

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07759245

Phase 2

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of REGN13335, an Anti-PDGF-B Monoclonal Antibody, in Adults With Pulmonary Arterial Hypertension

This study is researching an experimental drug called REGN13335. The study is focused on participants with Pulmonary Arterial Hypertension (PAH). The aim of th…

Pulmonary Arterial Hypertension (PAH)

Estimated

~$10 – $8,750

Regeneron PharmaceuticalsNCT07318597

Long-Term CLinical Evaluation of Aspiration ThRombectomy Using the Symphony or ProdIgy Thrombectomy System - CLEAR-IT

The study is designed to evaluate the short-term and long-term clinical performance and safety of the Symphony and Prodigy thrombectomy systems used in endovas…

Arterial ThromboembolismVenous ThromboembolismPulmonary Embolism

Estimated

~$10 – $1,050

Imperative Care, Inc.NCT07350499