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Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia
Schizophrenia - marked by delusions, hallucinations, and cognitive deficits - causes the most disability of any mental health condition, but existing treatment…
An Open-label Extension Study to Assess the Long-term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia
This is a Phase 3, multicenter, 52-week, outpatient, open-label extension (OLE) study to evaluate the long-term safety and tolerability of adjunctive KarXT in …
Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 2)
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from H coil combined with cog…
Motivation Skills Training to Enhance Functional Outcomes for People With Schizophrenia
This study will take place at four outpatient clinics serving adults with serious mental illness. Informed consent will be obtained from N=80 individuals with …
Activities to Change Your Mood: A Test of the Acceptability and Initial Efficacy in Clinical Samples and Healthy Controls
This is a study investigating how brief online activities can influence mood and attitudes.
Impact of Cerebellar TMS on Brain and Cognitive Functions in Schizophrenia: a Pilot Study
This is a single-site, sham-controlled, randomized trial in a total of 40 subjects between ages 18 and 60 years with schizophrenia. This study will investigate…
Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS f…
Testing the Role of Belief Updating in Persecutory Delusions
The goal of this clinical trial is to learn whether learning and belief updating change in response to the treatment of persecutory delusions, in individuals w…
Phase 3, Randomized, 28 Days, Double-blind, Placebo-controlled, Multicenter Study to Assess the Safety and Efficacy of Brilaroxazine (RP5063) in Subjects With Schizophrenia, Followed by a 52-Week Open-label Extension
This study is to evaluate the effect and safety of Brilaroxazine in patients with acute schizophrenia compared to the placebo short and long-term. Brilaroxazin…
A Randomized Controlled Trial of Taking Action Planning for College Students With Serious Mental Illnesses
The goal of this research is to investigate whether a peer-delivered illness self-management program called Taking Action can help college students with seriou…
Empirical Validation of a Cerebellar-cortical Hallucination Circuit
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study how hallucinations work in schizophrenia. TMS is a noninvasive…
Optimization of Neurophysiologic Biomarkers for Rehabilitation Interventions in Veterans With Chronic Psychosis
Cognitive symptoms of schizophrenia interfere with daily life-from managing self-care, to more complex tasks like taking medications and living independently. …