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Genetic Analysis of Immune Disorders
The purposes of this study are to 1) identify the genes responsible for certain immune disorders, 2) learn about the medical problems they cause, and 3) learn …
DOK 8STAT1GATA2+2 more
National Institute of Allergy and Infectious Diseases (NIAID)NCT00001467
Remote eligible
Novel Genetic Disorders of the Immune System
Background: \- The immune system helps the body fight infection and disease. People with immune system problems can get infections, blood disorders, and other…
PI3KCDCTLA4STAT3GOF+1 more
National Institute of Allergy and Infectious Diseases (NIAID)NCT02257892
Phase 1
A Pilot Study to Evaluate the Safety and Tolerability of Baricitinib in Patients With Job s Syndrome With Lupus-like Disease and/or Atopic Dermatitis
Background: Autosomal dominant hyper-IgE syndrome (HIES), also called Job syndrome, is a genetic disorder that affects the immune system. It can cause skin an…
Hyper IgE Syndrome From STAT3 MutationJob s SyndromeHIES+2 more
National Institute of Allergy and Infectious Diseases (NIAID)NCT07262983
Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)
The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome…
InfectionsPneumoniaImmune System Diseases+2 more
National Institute of Allergy and Infectious Diseases (NIAID)NCT00006150