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1,369 recruiting studies matching your filters

A Phase 1, Randomized, Double-blind, Placebo-controlled, Dose Escalation Study Evaluating Safety and Pharmacokinetics of VX-272 in Healthy Subjects

The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of single and multiple ascending doses of VX-272 in combination with deu…

Cystic Fibrosis

Estimated

~$10 – $8,750

Vertex Pharmaceuticals IncorporatedNCT07437105

Phase 1

RALLY-MF: A Phase 1b/2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of DISC-0974 in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

This phase 1b/2a open-label study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and clinical activity of DISC-0974 as well as cat…

Myelofibrosis; AnemiaAnemiaMyelofibrosis+4 more

Estimated

~$10 – $8,750

Disc Medicine, IncNCT05320198

Observational

The Use of Repetitive Transmagnetic Stimulation to Target Craving in Methamphetamine Use Disorder

The primary aim of this project is to use a randomized single-blind sham-controlled study to investigate if high frequency repetitive transmagnetic stimulation…

Methamphetamine AbuseSubstance Use DisordersStimulant Dependence+3 more

Estimated

~$10 – $6,250

Oregon Health and Science UniversityNCT03470480

Phase 1

Phase I/II Study of the Combination of Blinatumomab and Asciminib in Patients With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

To learn if the combination of blinatumomab and asciminib can help to control Ph+ ALL.

Philadelphia Chromosome-PositiveAcute Lymphoblastic Leukemia

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT06308588

Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkins Lymphoma Post CAR-T Treatment

This study evaluates immune responses after CAR-T therapy to find out if CAR-T therapy reduces the effectiveness of the vaccines (vaccine immunity) against dis…

Chronic Lymphocytic LeukemiaDiffuse Large B-Cell LymphomaFollicular Lymphoma+4 more

Estimated

~$10 – $1,125

OHSU Knight Cancer InstituteNCT06784167

Observational

Supporting Just-In-Time Consent for Prenatal Screening: The INFORM Study

This clinical trial is about prenatal genetic screening. It will test an intervention to help people make decisions about screening. The intervention is a shor…

Delivery of Health CareGenetic TestingHumans+9 more

Estimated

~$10 – $6,250

Case Western Reserve UniversityNCT07557303

Phase 2

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Brenipatide in the Treatment of Adult Participants With IBS-C

The purpose of this study is to evaluate how well brenipatide (LY3537031) is tolerated what side effects may occur, and the safety and efficacy in participants…

Irritable Bowel SyndromeConstipation

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07545772

Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)

Objective: Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) is a rare neurologic disorder that affects less th…

HTLV-I InfectionTropical Spastic Paraparesis

Estimated

~$10 – $675

National Institute of Neurological Disorders and Stroke (NINDS)NCT00001778

Phase 2

A Randomized Phase II Study Comparing Cytarabine + Daunorubicin (7 + 3) vs (Daunorubicin and Cytarabine) Liposome, Cytarabine + Daunorubicin + Venetoclax, Azacitidine + Venetoclax, and (Daunorubicin and Cytarabine) Liposome + Venetoclax in Patients Aged 59 or Younger Who Are Considered High-Risk (Adverse) Acute Myeloid Leukemia As Determined by MYELOMATCH; A MYELOMATCH SubStudy

This phase II MyeloMATCH treatment trial tests whether the standard approach of cytarabine and daunorubicin in comparison to the following experimental regimen…

Acute Myeloid LeukemiaAcute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative NeoplasmAcute Myeloid Leukemia Post Cytotoxic Therapy+1 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)

Autosomal Dominant Polycystic Kidney Disease Patient Registry

The purpose of the ADPKD Registry is to create an online patient network that includes at least 5,000 people with Autosomal Dominant Polycystic Kidney Disease …

Polycystic Kidney Diseases

Estimated

~$10 – $750

PKD FoundationNCT04039061

Phase 1

A Platform Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibito…

Colorectal CancerCRCPancreatic Ductal Adenocarcinoma+3 more

Estimated

~$10 – $8,750

Revolution Medicines, Inc.NCT06445062

Observational

Improving Cardiovascular Health in Veterans With PTSD by Treating Trauma-Related Nightmares With NightWare

The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans…

Post-traumatic Stress Disorder (PTSD)Cardiovascular DiseasesAutonomic Dysfunction+4 more

Estimated

~$10 – $5,625

VA Office of Research and DevelopmentNCT06419959