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Mechanistic Assessment of Norepinephrine TheRapy vs. Angiotensin-II in Septic Shock (MANTRA) Grant Submission- Dysfunctional Renin-Angiotensin System in Septic Shock

Despite best therapy efforts, sepsis and septic shock are associated with mortality rates of up to 40%. This clinical trial will determine the benefit of exoge…

Septic Shock

Estimated

~$10 – $6,250

Wake Forest University Health SciencesNCT06746753

Phase 3

Massive Transfusion in Children: a Platform RCT of Whole Blood Compared to Component Therapy and Tranexamic Acid to Placebo in Life-threatening Traumatic Bleeding

The MATIC-2 is a multicenter clinical trial enrolling children who are less than 18 years of age with hemorrhagic shock potentially needing significant blood t…

Hemorrhagic ShockTrauma Injury

Estimated

~$10 – $7,500

Philip SpinellaNCT06070350

Clinical Evaluation of Using NIRSense Sensor Patch to Measure Microvascular Perfusion Responses and Predict Decompensation in Cardiogenic Shock Patients

This is a prospective, single-center, observational pilot study of the investigational NIRSense Tissue Oximetry Sensor System (Envello Core), a noninvasive wea…

Cardiogenic ShockAcute Myocardial InfarctionAcute Decompensated Heart Failure

Estimated

~$10 – $1,050

NIRSense Inc.NCT07825363

Observational

Initiation and Titration of Guideline Directed Medical Therapy in Heart Failure Cardiogenic Shock With Impella 5.5 for Cardiac Recovery: INTeGRATE

The study will evaluate the impact of a combined device-drug strategy with Impella 5.5 with best practices and optimized GDMT on heart recovery outcomes in pat…

Heart FailureCardiogenic ShockReduced Ejection Fraction Heart Failure

Estimated

~$10 – $8,750

Abiomed Inc.NCT06965504

Phase 4

ANGIOtensin II for Septic Shock in the Emergency Department: ANGIO-ED Study

This pilot study will enroll 20 patients with septic shock and require emergent vasopressor support in the emergency department (ED). The primary objective of …

Septic Shock

Estimated

~$10 – $7,500

Brett A FaineNCT06693726

Phase 4

Clinical Decision Support Assistance to Randomize Patients to Early or Late Adjunctive Vasopressin in Septic Shock

The goal of the CASPER-Pilot study is to develop clinical decision support (CDS) technology within Epic to randomize patients with septic shock to early versus…

SepsisSeptic Shock

Estimated

~$10 – $6,250

The Cleveland ClinicNCT06709573

Observational

Personalized Fluid Resuscitation for Improved Sepsis Resuscitation Quality in the Emergency Department

The goal of this pilot clinical trial is to learn if a fluid assessment using non-invasive cardiac output monitoring (NICOM) is helpful for patients with sepsi…

SepsisSeptic Shock

Estimated

~$10 – $8,750

Intermountain Health Care, Inc.NCT07779720

Phase 4

Dopamine vs. Norepinephrine in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure and Systemic Hypotension Due to Pulmonary Hypertension: A Pilot Trial

This pilot randomized clinical trial compares dopamine and norepinephrine as first-line vasoactive therapies in term and late preterm neonates with pulmonary h…

Hypotension and ShockPulmonary Hypertension of the Newborn (PPHN)Hypoxemic Respiratory Failure

Estimated

~$10 – $6,250

University of California, DavisNCT07322133

Phase 2

CORTISHOCK-P: A Randomized Pilot Trial of Corticosteroids as a Pharmacologic Adjunct to Temporary Mechanical Circulatory Support in Inflammation-Enriched Heart Failure Cardiogenic Shock

This pilot study investigates whether giving a short course of intravenous corticosteroids (methylprednisolone) alongside standard medical care can help patien…

Cardiogenic ShockHeart FailureInflammation

Estimated

~$10 – $6,250

Brigham and Women's HospitalNCT07461961

Phase 3

Trauma Resuscitation With Low-Titer Group O Whole Blood or Products

The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate comp…

Wounds and InjuriesShock, Hemorrhagic

Estimated

~$10 – $6,250

University of Alabama at BirminghamNCT05638581

Phase 2

Multicenter Trial to Evaluate the Safety and Effectiveness of the Cardiohelp System for up to 30 Days of Support in Children With Severe Cardiac Failure

There are two primary goals of this multicenter clinical trial that combines an FDA device trial and a phase II drug trial in the same study cohort. These two …

Heart FailureCardiogenic ShockCongenital Heart Disease+1 more

Estimated

~$10 – $6,250

Stanford UniversityNCT06080074

Observational

COMPARE-VENT Feasibility Pilot Study: A Pragmatic Cluster Randomized Crossover Trial for Ventilation Strategies and Hemodynamic Impact in Critically Ill Patients With Cardiovascular Disease

Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly o…

Respiration FailureCardio Vascular DiseaseCardiogenic Pulmonary Oedema+4 more

Estimated

~$10 – $6,250

Mayo ClinicNCT07656259