Browse studies

Find your next paid study

132 recruiting studies matching your filters

Proof-of-concept Study of Nicotinamide and Oral Tetrahydrouridine (THU) and Decitabine to Treat High Risk Sickle Cell Disease

A randomized control trial in 20 subjects with sickle cell disease comparing oral THU-decitabine to nicotinamide and in combination (THU, decitabine and nicoti…

Sickle Cell Disease

Estimated

~$10 – $8,750

EpiDestiny, Inc.NCT04055818

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Background: Blood disorders like sickle cell disease and malaria affect many people around the world. Researchers want to learn more about blood disorders. To…

Alpha and Beta ThalassemiaSickle Cell DiseaseMalaria+1 more

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT03937817

Observational

Revamping Exercise Assessments in Child Health (Project REACH)

This study is a cooperative investigation funded by the NIH. The project is a collaboration among three major NIH Clinical Translational Science Awardees: 1) U…

Cystic FibrosisSickle Cell DiseaseSARS CoV 2 Infection

Estimated

~$10 – $6,250

University of California, IrvineNCT05359991

High Sensitivity Screening of Compound Libraries to Discover a Drug for the Treatment of Sickle Cell Disease

This study will collect representative blood samples from healthy children and adults and from children and adults who have unique red blood cell features that…

Sickle Cell TraitSickle Cell DiseaseSickle Cell Anemia

Estimated

~$10 – $675

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT00542230

Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

Background: People with sickle cell disease (SCD) have problems with their heart, brain, kidneys, liver, and lungs as they age. These problems may improve aft…

Mortality in Sickle CellSickle Cell Cardiopulmonary ComplicationsSickle Cell Organ Damage+2 more

Estimated

~$10 – $675

National Heart, Lung, and Blood Institute (NHLBI)NCT05213572

Phase 1

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

Background: Sickle cell disease (SCD) is an inherited disorder of the blood. SCD causes red blood cells (RBCs) to die early. This can lead to a shortage of he…

Sickle Cell DiseaseThalassemiaHemoglobinopathy

Estimated

~$10 – $5,625

National Heart, Lung, and Blood Institute (NHLBI)NCT06313398

Phase 3

A Phase III, Multicenter, Randomized, Placebo Controlled, Double-blind Study to Assess Efficacy and Safety of Crizanlizumab (5 mg/kg) Versus Placebo, With or Without Hydroxyurea/Hydroxycarbamide Therapy, in Adolescent and Adult Sickle Cell Disease Patients With Frequent Vaso-Occlusive Crises

A phase III, multi-center, randomized, placebo-controlled, double-blind study to assess efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or …

Sickle Cell Disease

Estimated

~$10 – $8,750

Novartis PharmaceuticalsNCT06439082

Phase 3

A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease

The primary objective of this study is to determine the effect of mitapivat versus placebo on the need for transfusions in subjects with SCD.

Sickle Cell Disease

Estimated

~$10 – $8,750

Agios Pharmaceuticals, Inc.NCT07656415

Phase 1

A Phase 1b Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DISC-3405 in Participants With Sickle Cell Disease

This is an open-label, multicenter, within-participant dose-escalation study examining up to 3 dose levels of DISC-3405 and will assess the safety, tolerabilit…

Sickle Cell Disease

Estimated

~$10 – $8,750

Disc Medicine, IncNCT07187973

Observational Study of Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease

Background: Sickle Cell Disease (SCD) causes blood cells form a crescent shape. It is caused by a genetic mutation in the hemoglobin gene. People with SCD are…

Sickle Cell Disease

Estimated

~$10 – $675

National Institutes of Health Clinical Center (CC)NCT05170412

Phase 3

An Open-label, Multi-centre, Rollover Study to Characterise Long-term Safety and Efficacy of Etavopivat in Adults, Adolescents and Children Who Have Sickle Cell Disease or Thalassaemia and Have Completed a Treatment Period in an Etavopivat Study

Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are…

Sickle Cell DiseaseThalassemia

Estimated

~$10 – $7,500

Novo Nordisk A/SNCT06609226

Phase 1

A Phase I Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease

Background: Sickle cell disease (SCD) is a genetic disease that causes the body to produce abnormal ( sickled ) red blood cells. SCD can cause anemia and life…

Sickle Cell DisordersSickle Cell DiseaseHemoglobin S+2 more

Estimated

~$10 – $5,625

National Heart, Lung, and Blood Institute (NHLBI)NCT05904093