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Phase 2
Cardiac and Metabolic Effects of Dapagliflozin in the Failing Fontan Circulation: A Phase II, Prospective, Double-Blind Study
The purpose of this research is to determine whether treatment with the study drug dapagliflozin for 3 months affects peripheral venous pressure at rest and du…
Fontan CirculationSingle Ventricle Heart DiseaseHFpEF - Heart Failure With Preserved Ejection Fraction
Mayo ClinicNCT06762964
Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i (ACHIEVE-SGLT2i) Registry
This real-world, international registry aims to evaluate the current experience with sodium-glucose cotransporter 2 inhibitors (SGLT2i) in adult congenital hea…
Adult Congenital Heart DiseaseCongenital Heart DiseaseSystemic Right Ventricle+5 more
Leiden University Medical CenterNCT06932081
Phase 3
Fontan Udenafil Exercise Longitudinal Assessment Trial (FUEL-2)
This study will evaluate the clinical efficacy and safety of udenafil, an orally administered, potent and selective inhibitor of PDE5, versus placebo for the t…
Single Ventricle Heart Disease
Mezzion Pharma Co. LtdNCT05918211