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Contralaterally Controlled FES Combined With Brain Stimulation for Severe Upper Limb Hemiplegia
This study is a necessary and important step in the development of a new therapy for upper limb functional recovery in patients with severe motor impairment. I…
TENS (Transcutaneous Electrical Nerve Stimulation): Effect of Transcutaneous Spinal Direct Current Stimulation on Lower Limb Reflex, Volitional, and Functional Movement Post-stroke
The subjects will be asked to attend minimum 15 separate sessions, 6 for testing changes in reflex behaviors, 3 for testing changes in the influence of descend…
Cerebral Oxygen Metabolism in Children
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. …
Error-enhanced Learning & Recovery in 2 & 3 Dimensions
This study is being done to see how errors lead to improvement. Specifically, we are evaluating the errors stroke participants make during an upper extremity e…
Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future
Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 followi…
Develop and Validate Machine-Learning Algorithm to Detect Atrial Fibrillation With Wearable Devices
Atrial Fibrillation (AF) is an abnormal heart rhythm. Because AF is often asymptomatic, it often remains undiagnosed in the early stages. Anticoagulant therapy…
Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training
The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-…
Allopregnanolone (Zuranolone) in Post-stroke Depression
The goal of this Phase II clinical trial is to learn if the oral synthetic allopreganolone analog (zuranolone) is safe to take and is well tolerated by stroke …
Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct 2
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinica…
Effect of Oral Minocycline in Patients With Acute Stroke - a Randomized, Open Label, Prospective Trial
The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acut…
Evidence-based Modeling for Acquired Dyslexia Treatments
This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired …
The Efficacy of a Frequency-tuned Electromagnetic Field Treatment in Facilitating the Recovery of Subacute Ischemic Stroke Patients - a Pivotal Study (the "EMAGINE 2.0" Study)
This is a multicenter study that will be conducted at approximately 20 centers and up to 30 centers, if the sample size will be increased following interim ass…