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Phase 1
A First-in-human Phase I Single-agent Dose-escalation, Food Effect and Dose Expansion Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
The primary objective of this Phase 1, open-label, dose-escalation, and exploratory study is to evaluate the safety and tolerability profile (establish the max…
Central Nervous System NeoplasmsGlioblastomaGliosarcoma, Adult+20 more
Jazz PharmaceuticalsNCT04541082
Phase 1
Robust Armored Dual-Cytokine (IL-15/IL-21) GPC3-CAR T Cells for Atypical Teratoid Rhabdoid Tumors and Central Nervous System Rhabdoid Tumors (RADIANT)
This study is being conducted in patients with GPC3-positive brain tumors that have recurred or have not responded to standard therapy. Atypical teratoid rhabd…
Atypical Teratoid Rhabdoid TumorCentral Nervous System Rhabdoid Tumor
Baylor College of MedicineNCT07513194